Drug exposure and minimum inhibitory concentration predict pulmonary tuberculosis treatment response

X Zheng, Z Bao, LD Forsman, Y Hu… - Clinical Infectious …, 2021 - academic.oup.com
… drugs predictive of sputum culture conversion and treatment outcome, as well as to explore
the association between drug … Acute kidney injury (AKI) was defined as an increase in serum

A systematic review and meta-analysis of first-line tuberculosis drug concentrations and treatment outcomes

R Perumal, K Naidoo, A Naidoo… - … of Tuberculosis and …, 2020 - ingentaconnect.com
… for predicting treatment failure or relapse.If it is true that low drug serum concentrations
therefore not representative of all patients with pulmonary TB.Six studies reported loss to follow-…

Longitudinal pharmacokinetic-pharmacodynamic biomarkers correlate with treatment outcome in drug-sensitive pulmonary tuberculosis: a population pharmacokinetic …

F Kloprogge, HC Mwandumba, G Banda… - Open forum …, 2020 - academic.oup.com
… to explore predictors for treatment outcome using baseline … bacillary load data from
drug-sensitive TB patients. Specific … and baseline serum bilirubin concentrations positively …

The impact of first-line anti-tubercular drugs' pharmacokinetics on treatment outcome: a systematic review

T Sileshi, E Tadesse, E Makonnen… - … : advances and …, 2021 - Taylor & Francis
serum concentrations of anti-TB drugs with poor treatment … low RMP concentration as a
predictive of treatment outcome. … lower peak concentration or AUC as a predictor of culture …

Plasma chemokines are baseline predictors of unfavorable treatment outcomes in pulmonary tuberculosis

NP Kumar, K Moideen, A Nancy… - Clinical Infectious …, 2021 - academic.oup.com
… of cavity, or severity of lung pathology (as … outcomes of our results. Our study innovates by
using a pure population of culture-positive, newly diagnosed, drug-sensitive, HIV-negative TB

Intrapulmonary pharmacokinetics of first-line anti-tuberculosis drugs in Malawian patients with tuberculosis

AD McCallum, HE Pertinez, LJ Else… - Clinical Infectious …, 2021 - academic.oup.com
… treatment outcomes in patients with pulmonary tuberculosis. … In this study, drug concentrations
in lung epithelial lining fluid … culture conversion was not predictive of clinical outcome (P < .…

Biomarkers that correlate with active pulmonary tuberculosis treatment response: a systematic review and meta-analysis

AJ Zimmer, F Lainati, N Aguilera Vasquez… - Journal of clinical …, 2022 - Am Soc Microbiol
… Continuous monitoring and early identification of people with TB who are at risk of poor treatment
outcomesprediction (7). For … Distinct serum biosignatures are associated with different …

Subtherapeutic rifampicin concentration is associated with unfavorable tuberculosis treatment outcomes

G Ramachandran, P Chandrasekaran… - Clinical Infectious …, 2020 - academic.oup.com
predictive of clinical outcomes in TB patients, but data are limited and are conflicting [12–14,
16]. Drug concentrations … In summary, our study among adult pulmonary TB patients treated …

… plasma matrix metalloproteinase and tissue inhibitors of matrix metalloproteinase levels with adverse treatment outcomes among patients with pulmonary tuberculosis

NP Kumar, K Moideen, A Nancy… - JAMA Network …, 2020 - jamanetwork.com
predictors, using TB treatment outcome as the main outcome … correlate with lung pathology,
with plasma concentrations of … Moreover, correlates of risk studies in plasma/serum have …

Drug exposure and susceptibility of second-line drugs correlate with treatment response in patients with multidrug-resistant tuberculosis: a multicentre prospective …

X Zheng, LD Forsman, Z Bao, Y Xie… - … Respiratory Journal, 2022 - Eur Respiratory Soc
… that treatment outcomes in patients with drug-susceptible TB … (previously reported to be
predictive of treatment outcome [24])… of moxifloxacin in patients with pulmonary tuberculosis. Am J …