Sex-dependent mechanisms of chronic pain: a focus on microglia and P2X4R
… briefly examine microglial P2X4R signaling in the spinal cord as it relates to chronic pain
through … Given the distinct microglial response to ATP in males and females, it was important to …
through … Given the distinct microglial response to ATP in males and females, it was important to …
Sex‐specific transcriptome of spinal microglia in neuropathic pain due to peripheral nerve injury
… neuropathic microglial signature and indicates distinct sex … of cytokine signaling 1), whereas
female microglia include … Neuroimmune sex-dependent differences in pain processing …
female microglia include … Neuroimmune sex-dependent differences in pain processing …
Sex differences in neuroimmune and glial mechanisms of pain
AM Gregus, IS Levine, KA Eddinger, TL Yaksh… - Pain, 2021 - journals.lww.com
… in a sex-dependent manner to influence the chronic pain phenotype. In … of cancer pain may
require several functionally distinct … underlying sex-dependent differences in pain signaling is …
require several functionally distinct … underlying sex-dependent differences in pain signaling is …
Neuropathic pain: mechanisms, sex differences, and potential therapies for a global problem
S Ghazisaeidi, MM Muley… - Annual Review of …, 2023 - annualreviews.org
… -glia interactions producing and regulating neuropathic pain … different aspects of nerve
injury–induced neuropathic pain, … mice: sex-dependent microglial signaling in the spinal cord. …
injury–induced neuropathic pain, … mice: sex-dependent microglial signaling in the spinal cord. …
Microglial diversity in neuropathic pain
… + microglia continuously repress pronociceptive signals even … the role of spinal microglia in
the induction of neuropathic pain, … The distinct roles of diverse microglia challenge previous …
the induction of neuropathic pain, … The distinct roles of diverse microglia challenge previous …
[HTML][HTML] Spinal cord microglia drive sex differences in ethanol-mediated PGE2-induced allodynia
SN Alexander, OA Reed, MD Burton - Brain, Behavior, and Immunity, 2024 - Elsevier
… a mechanism of mechanical allodynia unique to females. … behind the transition from acute
to chronic pain and parse out … signals and incomplete microglia, the “mask all” function was …
to chronic pain and parse out … signals and incomplete microglia, the “mask all” function was …
Sex differences in pain with emphasis on neuroimmune interactions
X Luo, J Ji, RR Ji - Neuroimmune Interactions in Pain: Mechanisms and …, 2023 - Springer
… macrophages may utilize signaling distinct from microglia to modulate chronic pain. In …
neuropathic pain in male but not female mice: sex-dependent microglial signaling in the spinal …
neuropathic pain in male but not female mice: sex-dependent microglial signaling in the spinal …
Sex differences in pain along the neuraxis
P Presto, M Mazzitelli, R Junell, Z Griffin… - …, 2022 - Elsevier
… in chronic pain disorders, preclinical pain studies have … disorders, potentially through
sex-dependent hormonal influences. … to many different neurochemicals and signaling molecules. …
sex-dependent hormonal influences. … to many different neurochemicals and signaling molecules. …
Microglial heterogeneity in chronic pain
G Sideris-Lampretsas, M Malcangio - Brain, Behavior, and Immunity, 2021 - Elsevier
… unique microglia transcriptional profile that is associated with … Microglia differentiate in a
sex-dependent fashion in the … peripheral signals and microglia, and orchestrate disruption of …
sex-dependent fashion in the … peripheral signals and microglia, and orchestrate disruption of …
[HTML][HTML] Interleukin-35 alleviates neuropathic pain and induces an anti-inflammatory shift in spinal microglia in nerve-injured male mice
NT Fiore, JP Hayes, SI Williams… - Brain, Behavior, and …, 2024 - Elsevier
… development of neuropathic pain in a sex-dependent manner in … -9 signaling in spinal
microglia and its role in neuropathic pain is … IL-35 can signal through different types of receptors (…
microglia and its role in neuropathic pain is … IL-35 can signal through different types of receptors (…