Siderophore conjugates to combat antibiotic-resistant bacteria
… in siderophore antibiotic conjugates and the challenges associated with the design of these
… in depth later in this review, designing a suitable linker to join the antibiotic of interest to a …
… in depth later in this review, designing a suitable linker to join the antibiotic of interest to a …
Platform to discover protease-activated antibiotics and application to siderophore–antibiotic conjugates
JH Boyce, B Dang, B Ary, Q Edmondson… - Journal of the …, 2020 - ACS Publications
… ), we synthesized WSWC conjugate 17. We also synthesized a siderophore-free conjugate
(18) … Here, we focused on delivering antibiotics by designing protease-cleavable siderophore …
(18) … Here, we focused on delivering antibiotics by designing protease-cleavable siderophore …
Biotechnological potential of Streptomyces siderophores as new antibiotics
… [100] adopted a dual drug conjugate with a siderophore linked to … siderophores produced
by Streptomyces, many new and effective siderophoreantibiotic conjugates could be designed …
by Streptomyces, many new and effective siderophoreantibiotic conjugates could be designed …
Antibiotic conjugates with an artificial MECAM-based siderophore are potent agents against Gram-positive and Gram-negative bacterial pathogens
… synthesized conjugates of antibiotics and artificial siderophores … For the design of
siderophore–antibiotic conjugates, it is … a sufficient engagement of the antibiotic target. To …
siderophore–antibiotic conjugates, it is … a sufficient engagement of the antibiotic target. To …
A novel natural siderophore antibiotic conjugate reveals a chemical approach to macromolecule coupling
T Caradec, E Anoz-Carbonell, R Petrov… - ACS Central …, 2023 - ACS Publications
… Few natural sideromycins have been discovered thus far, but they have served as invaluable
blueprints for the rational design of custom siderophores–antibiotic conjugates. These …
blueprints for the rational design of custom siderophores–antibiotic conjugates. These …
[HTML][HTML] Siderophore: a suitable candidate for drug delivery using the Trojan horse strategy
B Khasheii, P Mahmoodi… - Medical Laboratory …, 2021 - mlj.goums.ac.ir
… siderophore-antibiotic complexes has recently received much … the efficacy of
siderophore-antibiotic conjugates as a Trojan … design of siderophore-drug conjugates so that a …
siderophore-antibiotic conjugates as a Trojan … design of siderophore-drug conjugates so that a …
Siderophore-Based Drug Repurposing of Platinum Anticancer Agents as Targeted Antibiotics and Investigation of Pt-Induced DNA Damage in Gram-Negative …
C Guo - 2023 - dspace.mit.edu
… antibiotics. One promising approach involves the development of siderophore– antibiotic
conjugates (… Various linker options have been explored in the design of siderophore-antibiotic …
conjugates (… Various linker options have been explored in the design of siderophore-antibiotic …
A γ-lactam siderophore antibiotic effective against multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter spp.
JA Goldberg, V Kumar, EJ Spencer, D Hoyer… - European Journal of …, 2021 - Elsevier
… of a new class of siderophore-conjugated γ-lactam antibiotic … effectiveness of a novel γ-lactam
siderophore antibiotic. Our … by combining 2 with sulbactam, designing a novel γ-lactam BLI …
siderophore antibiotic. Our … by combining 2 with sulbactam, designing a novel γ-lactam BLI …
Conjugation to Native and Nonnative Triscatecholate Siderophores Enhances Delivery and Antibacterial Activity of a β-Lactam to Gram-Negative Bacterial Pathogens
… a novel Ent-inspired siderophore–antibiotic conjugate (SAC) employing an alternative
siderophore … Siderophore–antibiotic conjugates (SACs) are designed to hijack the active transport …
siderophore … Siderophore–antibiotic conjugates (SACs) are designed to hijack the active transport …
Emerging target-directed approaches for the treatment and diagnosis of microbial infections
MC Almeida, PM da Costa, E Sousa… - Journal of Medicinal …, 2022 - ACS Publications
… article, the term “siderophore–antibiotic conjugate” will still be used … siderophores and
siderophore mimetics will be made. … moieties are not required to design an efficient antimicrobial …
siderophore mimetics will be made. … moieties are not required to design an efficient antimicrobial …