… T reg cells are essential to maintain peripheral T cell tolerance and require IL-2R signaling
… genes in human CD45RO + T eff /memory T cells when compared to T reg cells 5 . …

… Depending on the concentration and duration of exposure, IL-2 induces different signals in
conventional T cells compared with T reg cells, which influences the outcome of a localized …

… explored ITK signaling in CD4+ T cells and its relationship with Th17 and Treg cells in a
mouse model of ALI. Our findings propose that inhibition of ITK signaling during ALI causes …

… Treg cells significantly ameliorated the development of GVHD. We have shown … T cells
deficient in Interleukin-2-inducible T cell kinase (Itk) reduce GVHD without affecting GVL function…

… of activated T cells, and is able to mediate human T cell growth … CD4+ T cells into T helper
1 (Th1) and T helper 2 (Th2) cells, … PHA as mitogens or Ags (the first signal of T lymphocyte …

… immune cells [2,27]… signaling in T cells and is being targeted to treat asthma and other
immune mediated disorders. Our study proposes that ITK signaling gets activated in CD4 + T cells …

… of multiple lymphocyte lineages. Deficiency of IL-2 family signaling pathway in mammals
prevents CD4 + T cells from developing effector functions and CD8 + T cells from developing …

… 149 amino acids containing a signal peptide of 20 amino acids. … high affinity and its signaling
function promotes the activation … Interleukin 2 is required as a growth factor for T cells for the …

… To determine if IL-2 and IL-2-REH elicit distinct signaling in Tregs and CD8+ T cells, we
analyzed STAT5 phosphorylation and transcriptional changes following cytokine stimulation ex …

… Consistently, Con A-induced T cell proliferation was also inhibited by TAS in vitro. Our … T
lymphocyte activation and cell proliferation by down-regulating IL-2 expression and its signaling …