DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer
RX Huang, PK Zhou - Signal transduction and targeted therapy, 2020 - nature.com
… (1) identifying the master regulator of the development and progression of RR and (2) determining
how … In this review, we discuss the promising targets of signaling pathways that can be …
how … In this review, we discuss the promising targets of signaling pathways that can be …
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
… defining major signaling pathways … signaling pathways and essential molecules of OA. We
have summarized the roles and functions of those pathological molecular signaling pathways …
have summarized the roles and functions of those pathological molecular signaling pathways …
Short lifespan of syngeneic transplanted MSC is a consequence of in vivo apoptosis and immune cell recruitment in mice
… time-course activation of HIF-1α signalling pathways post-transplantation. The results showed
a strong, yet transient, activation of hypoxia-induced signalling … interested in estimating the …
a strong, yet transient, activation of hypoxia-induced signalling … interested in estimating the …
[HTML][HTML] Aging and age‐related diseases: from mechanisms to therapeutic strategies
Z Li, Z Zhang, Y Ren, Y Wang, J Fang, H Yue, S Ma… - Biogerontology, 2021 - Springer
… and are a driving force for all age-related diseases. Human life expectancy has greatly …
Pharmacological or caloric restriction (CR) targeting nutrient signaling pathways have been …
Pharmacological or caloric restriction (CR) targeting nutrient signaling pathways have been …
[HTML][HTML] Beneficial and detrimental effects of reactive oxygen species on lifespan: a comprehensive review of comparative and experimental studies
HJ Shields, A Traa, JM Van Raamsdonk - Frontiers in cell and …, 2021 - frontiersin.org
… important roles in redox signaling pathways within the cell, … determined by levels of
ROS and antioxidants, determines … and muscle), when during the life cycle it is increased (eg, …
ROS and antioxidants, determines … and muscle), when during the life cycle it is increased (eg, …
Molecular mechanisms of dietary restriction promoting health and longevity
CL Green, DW Lamming, L Fontana - Nature Reviews Molecular Cell …, 2022 - nature.com
… geroprotective signalling pathways that promote healthy longevity. … It also extends life
expectancy and safeguards against … There has been significant interest in identifying rapamycin …
expectancy and safeguards against … There has been significant interest in identifying rapamycin …
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
… has promoted human health and greatly extended life expectancy, with the aging of society,
a … Furthermore, thorough research on the pathogenesis of aging to identify interventions that …
a … Furthermore, thorough research on the pathogenesis of aging to identify interventions that …
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
… We next use SenMayo to identify senescent hematopoietic or mesenchymal cells at the … the
single cell level and identify key intercellular signaling pathways. SenMayo also represents a …
single cell level and identify key intercellular signaling pathways. SenMayo also represents a …
Emerging trends in colorectal cancer: Dysregulated signaling pathways
R Ahmad, JK Singh, A Wunnava… - International …, 2021 - spandidos-publications.com
… The development of CRC may take several years by establishing the dysregulation of several
signaling pathways and avoiding multiple regulatory routes. Malignant cells arising in the …
signaling pathways and avoiding multiple regulatory routes. Malignant cells arising in the …
Unveiling the connection: long-chain non-coding RNAs and critical signaling pathways in breast cancer
… signaling pathways [3], [4]. By unravelling the intricate interplay between lncRNAs and critical
signaling pathways … of the condition and identify potential targets for treatment [2], [5]. The …
signaling pathways … of the condition and identify potential targets for treatment [2], [5]. The …