DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

RX Huang, PK Zhou - Signal transduction and targeted therapy, 2020 - nature.com
… (1) identifying the master regulator of the development and progression of RR and (2) determining
how … In this review, we discuss the promising targets of signaling pathways that can be …

Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
defining major signaling pathwayssignaling pathways and essential molecules of OA. We
have summarized the roles and functions of those pathological molecular signaling pathways

Short lifespan of syngeneic transplanted MSC is a consequence of in vivo apoptosis and immune cell recruitment in mice

MB Preda, CA Neculachi, IM Fenyo, AM Vacaru… - Cell death & …, 2021 - nature.com
time-course activation of HIF-1α signalling pathways post-transplantation. The results showed
a strong, yet transient, activation of hypoxia-induced signalling … interested in estimating the …

[HTML][HTML] Aging and age‐related diseases: from mechanisms to therapeutic strategies

Z Li, Z Zhang, Y Ren, Y Wang, J Fang, H Yue, S Ma… - Biogerontology, 2021 - Springer
… and are a driving force for all age-related diseases. Human life expectancy has greatly …
Pharmacological or caloric restriction (CR) targeting nutrient signaling pathways have been …

[HTML][HTML] Beneficial and detrimental effects of reactive oxygen species on lifespan: a comprehensive review of comparative and experimental studies

HJ Shields, A Traa, JM Van Raamsdonk - Frontiers in cell and …, 2021 - frontiersin.org
… important roles in redox signaling pathways within the cell, … determined by levels of
ROS and antioxidants, determines … and muscle), when during the life cycle it is increased (eg, …

Molecular mechanisms of dietary restriction promoting health and longevity

CL Green, DW Lamming, L Fontana - Nature Reviews Molecular Cell …, 2022 - nature.com
… geroprotective signalling pathways that promote healthy longevity. … It also extends life
expectancy and safeguards against … There has been significant interest in identifying rapamycin …

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
… has promoted human health and greatly extended life expectancy, with the aging of society,
a … Furthermore, thorough research on the pathogenesis of aging to identify interventions that …

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

D Saul, RL Kosinsky, EJ Atkinson, ML Doolittle… - Nature …, 2022 - nature.com
… We next use SenMayo to identify senescent hematopoietic or mesenchymal cells at the … the
single cell level and identify key intercellular signaling pathways. SenMayo also represents a …

Emerging trends in colorectal cancer: Dysregulated signaling pathways

R Ahmad, JK Singh, A Wunnava… - International …, 2021 - spandidos-publications.com
… The development of CRC may take several years by establishing the dysregulation of several
signaling pathways and avoiding multiple regulatory routes. Malignant cells arising in the …

Unveiling the connection: long-chain non-coding RNAs and critical signaling pathways in breast cancer

R Thapa, O Afzal, G Gupta, AA Bhat, WH Almalki… - … -Research and Practice, 2023 - Elsevier
signaling pathways [3], [4]. By unravelling the intricate interplay between lncRNAs and critical
signaling pathways … of the condition and identify potential targets for treatment [2], [5]. The …