… and cell–cell interactions and highlighting tumor heterogeneity. However, the mass cytometry
approaches … probes. Another distinct advantage of the droplet-based microfluidics for …

… we profile 233,591 single cells from patients with lung, colorectal, ovary and breast cancer (n
= 36) and construct a pan-cancer … Our approach was less successful for cancer cells, which …

… of endothelial cells (ECs) to block tumor … cancer using single-cell RNA sequencing in
combination with orthogonal bulk multi-omics approaches to provide a molecular atlas of tumor EC (…

… cells and immune cells, tumor heterogeneity, circulating … and immune cells because it can
probe cellular and … The 10X Genomics platform, which is based on a microfluidics approach, is …

… future studies on tumor heterogeneity and pave … probe the genomic profile of breast cancer,
we applied inferCNV algorithm to analyze the copy-number variants (CNVs) of a single cell…

… A study [32] probed the heterogeneity of CAFs in human primary prostate cancer by two
different scRNA-seq methods (10 × Chromium and Fluidigm C1) and identified six subgroups of …

… Tumor heterogeneity is a key characteristic of malignant … Herein, we review the steps and
methods of single-cell … Then, we isolate a single cell and move on to the downstream analysis (…

… heterogeneity, we applied a computational approach (inferCNV) … than intra-tumoral
heterogeneity (Fig. 4a). We noted that … in MCL to reveal tumor heterogeneity, to track clonal …

… Cancer arises from a single cell through a series … single-cell studies where sequencing
depth has been an issue. However, these approaches lack the ability to prospectively probe cell …

… probes (median of 10 probes/target mRNA) for each gene of interest for a total of 18,120
probes, … In this study, we used a robust approach for quantitative spatial molecular profiling to …