[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
… Carriers of small isoforms with up to 22 kringle IV domainskringle consisting of two short
exons, spaced by a mostly ≈4 … by several functional single nucleotide polymorphisms (SNPs) (…

The kringle IV type 2 domain variant 4925G> A causes the elusive association signal of the LPA pentanucleotide repeat

R Grüneis, H Weissensteiner, C Lamina… - Journal of Lipid …, 2022 - ASBMB
… for apolipoprotein(a) [apo(a)], which consists of 10 different kringle IV domains (KIV-1 to
KIV-10)… repeat (STR) located 1.3 kb upstream from the first exon of LPA (hg19 chr6:161,086,617–…

Lipoprotein (a) concentration, genetic variants, apo (a) isoform size, and cellular cholesterol efflux in patients with elevated Lp (a) and coronary heart disease …

C Stefanutti, L Pisciotta, E Favari, S Di Giacomo… - Journal of Clinical …, 2020 - Elsevier
… The kringle IV type 2 (KIV-2) domain is further expanded resulting … single-nucleotide
polymorphisms [SNPs] in the protease … on exon 26; in our study, we identified this variant in 4

Nonsynonymous SNPs in LPA homologous to plasminogen deficiency mutants represent novel null apo (a) alleles [S]

BM Morgan, AN Brown, N Deo, TWR Harrop… - Journal of Lipid …, 2020 - ASBMB
… Imaging of the recombinant apo(a) proteins in conjunction with … correct folding of the apo(a)
kringle structure and mutations at … (a) kringles IV types 6 to 10 domain affect Lp(a) plasma …

[HTML][HTML] Lipoprotein (a) measurement issues: are we making a mountain out of a molehill?

F Kronenberg - Atherosclerosis, 2022 - Elsevier
… a kringle-V (KV) and a protease domain. The KIV elements of … coding exons are highly
homologous to the respective exons … of KIV repeats or single nucleotide polymorphisms (SNPs) …

Digital droplet PCR versus quantitative PCR for lipoprotein (a) kringle IV type 2 repeat polymorphism genetic characterization

G Barbieri, G Cassioli, A Kura, R Orsi… - Journal of Clinical …, 2024 - Wiley Online Library
… (GWAS) identified more than 200 single nucleotide polymorphisms (SNPs), which might …
, including both exons 4 and 5 encoding kringle IV type 2 (KIV2) protein domain, represents its …

Lipoprotein (a)

MB Boffa, ML Koschinsky - Biochemistry of Lipids, Lipoproteins and …, 2021 - Elsevier
Apo(a) lacks the tail domain and kringles 1–3 and consists of multiple copies of a kringle 4-like
sequence (IV 1 to IV 10 ), a kringle … arising from alternative splicing or exon skipping). The …

Ancestry specific distribution of LPA Kringle IV-Type-2 genetic variants highlight associations to apo (a) copy number, glucose and hypertension.

Y Li, F Kronenberg, S Coassin, B Vardarajan… - medRxiv, 2024 - medrxiv.org
… is encoded by a 5.6 kb-sized region that contains 2 exons (… various single nucleotide
variants and mutations 8, … A polymorphism in the protease-like domain of apolipoprotein(a) is …

Prevalence and influence of LPA gene variants and isoform size on the Lp (a)-lowering effect of pelacarsen

E Karwatowska-Prokopczuk, N Clouet-Foraison, S Xia… - Atherosclerosis, 2021 - Elsevier
… alleles with a low number of Kringle IV type 2 (KIV 2 ) repeats… region of the protease-like
domain. However, there is no … to an exon 24–25 splice site of the mature human apolipoprotein(a…

A Novel Mutation in the Kringle IV Domain of LPA Gene Leading to Familial Cardiovascular Diseases

Y Li, X Zhang, Y Wang, F Gong, X Yu, T Zhang - 2020 - researchsquare.com
… , including both SNVs (single nucleotide variants) and CNVs (… every apo(a) gene, while the
copy number of Kringle IV type … of 3-16 exon in the Kringle IV domain of LPA gene and risk of …