Novel, non-nitrocatechol catechol-O-methyltransferase inhibitors modulate dopamine neurotransmission in the frontal cortex and improve cognitive flexibility
S Byers, IP Buchler, M DePasquale, HL Rowley… - …, 2020 - Springer
… Catechol-O-methyltransferase (COMT) inhibitors modulate cortical dopaminergic function
and have been proposed as potential cognitive enhancers. Unfortunately, currently available …
and have been proposed as potential cognitive enhancers. Unfortunately, currently available …
Catechol-O-methyltransferase gene Val158Met polymorphism and obsessive compulsive disorder susceptibility: a meta-analysis
P Kumar, V Rai - Metabolic brain disease, 2020 - Springer
… Catechol-O-methyltransferase (COMT) is an important enzyme involved in the metabolic
inactivation of the dopamine … COMT inactivates dopamine in prefrontal cortex region of brain …
inactivation of the dopamine … COMT inactivates dopamine in prefrontal cortex region of brain …
[HTML][HTML] Brain network connectivity and association with catechol-o-methyltransferase gene polymorphism in Korean attention-deficit hyperactivity disorder children
JH Park, YD Son, Y Kim, DH Han - Psychiatry Investigation, 2020 - ncbi.nlm.nih.gov
… The availability of DA and NE in the prefrontal cortex is mainly affected by COMT enzymes
[ 56 ]. Recent research showed that altered dopaminergic and noradrenergic tone, affected by …
[ 56 ]. Recent research showed that altered dopaminergic and noradrenergic tone, affected by …
Balance between transmitter availability and dopamine D2 receptors in prefrontal cortex influences memory functioning
G Papenberg, N Karalija, A Salami… - Cerebral …, 2020 - academic.oup.com
… Catechol-O-Methyltransferase polymorphism served as genetic proxy for endogenous prefrontal
… For instance, the catechol-O-methyltransferase (COMT) Val158Met polymorphism gives …
… For instance, the catechol-O-methyltransferase (COMT) Val158Met polymorphism gives …
Distinct roles for dopamine clearance mechanisms in regulating behavioral flexibility
C Korn, T Akam, KHR Jensen, C Vagnoni… - Molecular …, 2021 - nature.com
… particularly by catechol-O-methyltransferase (COMT), is more prominent in prefrontal cortex
(… These results, however, contrast with a report of differences in dopamine overflow in COMT …
(… These results, however, contrast with a report of differences in dopamine overflow in COMT …
Investigating interactive effects of worry and the catechol-o-methyltransferase gene (COMT) on working memory performance
… , dopamine in the prefrontal cortex heavily influences the stability of mental representations
during working memory tasks, yet no research has probed its role in … role of dopamine on the …
during working memory tasks, yet no research has probed its role in … role of dopamine on the …
Estradiol and the catechol-o-methyltransferase gene interact to predict working memory performance: a replication and extension
… Decades of evidence across taxa have established the importance of dopamine (DA) … using
the catechol-o-methyltransferase (COMT) gene as a proxy for basal prefrontal DA tone. The …
the catechol-o-methyltransferase (COMT) gene as a proxy for basal prefrontal DA tone. The …
Catechol-O-Methyltransferase Effects on Smoking: A Review and Proof of Concept of Sex-Sensitive Effects
EE DeVito, M Sofuoglu - Current behavioral neuroscience reports, 2022 - Springer
… ’s effects on dopamine metabolism in the brain (including in subcortical and prefrontal cortical
… only in higher basal synaptic dopamine levels (primarily in the prefrontal cortex (PFC) but …
… only in higher basal synaptic dopamine levels (primarily in the prefrontal cortex (PFC) but …
Catechol-O-methyltransferase (COMT) Val158Met Polymorphism and susceptibility to alcohol dependence
A Chaudhary, P Kumar, V Rai - Indian Journal of Clinical Biochemistry, 2021 - Springer
… Several articles investigated catechol-O-methyltransferase (COMT) Val158Met polymorphism
… In prefrontal cortex (PF), COMT mainly controls the dopaminergic transmission, because …
… In prefrontal cortex (PF), COMT mainly controls the dopaminergic transmission, because …
Effects of catechol-O-methyltransferase inhibition on effort-related choice behavior in male mice
… -released dopamine. COMT is the predominate regulator of dopamine turnover in regions
of the brain with low levels of dopamine transporters, including the prefrontal cortex. Here, we …
of the brain with low levels of dopamine transporters, including the prefrontal cortex. Here, we …