… between direct and indirect regulation by Six1, ChIP … is similar to the OV stage studied
herein, identified Six1 binding sites in close proximity to eya2, prdm1, spry1 and zbtb16 genes [42]…

… in this gene result in BOS/BOR, our goal was to determine whether these mutations have …
with mammals, we expressed Xenopus Six1 proteins carrying the human mutations in a wild-…

… associated with the pathogenicity of targeted variants in CLIC5A and SLC12A2, found in
two … The three proteins (SLC12A2, SIX1, and SIX4) were analyzed on the STRING database …

… how Six1 and co‐factors interact to direct developmental … genes are directly regulated by
Six1. Sorting through all these excellent data sets for those genes that are direct targets of Six1 …

… Eya1 does not have direct DNA-binding ability. Instead, it … transcriptional activation of
downstream targets required for the … genes known to be associated with BOR or BOS: EYA1, SIX1, …

… SIX1 target genes (CCNA1, TGFB1, GDNF, and SLC12A2) … and His-EYA1 proteins and
verified their direct interactions … using these two recombinant proteins by binding GST-SIX1 to …

… therapy medicines or medicines that target the HER2 protein 1,2 . A limited number of
options … Here, we identified SMAD5 as a direct target of ROCK1 kinase. The RhoC/ROCK1/SMAD5 …

… SIX1 and SIX4 target genes identified Myog and Myf5 as Six 1 target genes and loss of Six1
… A study conducted in colon cancer identified Smad7 as a direct target of MicroRNA-25 (miR-…