… relative expression of the target gene was calculated by 2… HIF-1α, Snail and E-cadherin,
Spearman method was adopted to verify it, and we found that the expression of HIF-1α and Snail …

… of FBP1 and inhibit the expression of Snail, HIF‑1α and VEGF in … upregulated HIF‑1α/VEGF
signaling pathways via the Snail‑… cancer progression, is a HIF-1α target gene. VEGF has also …

… , phosphorylated TOPK, HIF-1α and Snail was significantly … mRNA and protein levels
of HIF-1α and Snail. Interestingly, TOPK … The ON-TARGET plus nontargeting pool and ON-TARGET …

… (E) ChIP–qPCR was performed to identify hCINAP as a direct binding target of HIF-1α–ARNT.
H3, histone H3; N, normoxia; H, hypoxia. Data presented are the mean ± SEM for 3 …

… of a series of downstream target genes such as growth factors … activation effectors of target
genes, controlling the intricate … Meanwhile, the promoter region of Snail is directly contacted …

… blocks HIF interaction with p300 or CBP and prevents transcription of target genes (40–42). …
This study also showed the elevation of Snail mRNA expression level after HIF-1α …

… (Snail) and five (Slug) zinc fingers and is involved in the binding of the proteins to the target
gene … demonstrate that HIF-1α regulates the activation of EMT, increasing the Snail level in …

… HIF-1α regulates Snail expression by activating the promoter through binding to two hypoxia
response elements (HREs) in the snail … of HIF-1α and HIF-1α downstream target genes …

… effects on gene expression; it can repress gene expression by … that HECTD1 is a SNAIL
target gene. The accumulation of … non-hypoxic conditions that induce HIF-1α stabilization or …

… Our results revealed that three positive feedback loops, composed of HIF-1α and its three
targets SNAIL, TWIST, and miR-210, should be sequentially activated to induce EMT under …