Histone deacetylases inhibitors in neurodegenerative diseases, neuroprotection and neuronal differentiation

S Shukla, BL Tekwani - Frontiers in pharmacology, 2020 - frontiersin.org
… The global co-activator includes p300 and CREB binding Protein. Nuclear receptor co-…
in neuronal differentiation and neuroprotection in different cell lines, in vivo preclinical animal …

Beneficial and sexually dimorphic response to combined HDAC inhibitor valproate and AMPK/SIRT1 pathway activator resveratrol in the treatment of ALS mice

O Bankole, I Scambi, E Parrella, M Muccilli… - International Journal of …, 2022 - mdpi.com
effect was associated with an overall neuroprotective effect … -apoptotic effect by upregulating
Bcl-xL expression in vivo [48]… beneficial role in ALS, exerting both neuroprotective and anti-…

[HTML][HTML] Therapeutic potential of lithium chloride and valproic acid against neuronopathic types of mucopolysaccharidoses through induction of the autophagy process

L Gaffke, N Firyn, E Rintz, K Pierzynowska… - Archives of Biochemistry …, 2023 - Elsevier
… It can also act through autophagy induction. Similarly, some of the proposed … through which
LiCl may exert its therapeutic effects in neurodegenerative conditions include neuroprotection

Opportunities for histone deacetylase inhibition in amyotrophic lateral sclerosis

YE Klingl, D Pakravan… - British Journal of …, 2021 - Wiley Online Library
… both cultured neurons and in vivo models of neurodegeneration. Taken … In addition, it exerts
a neuroprotective role through … Due to their neuroprotective effects, valproate and lithium are …

HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo

S Sanna, S Esposito, A Masala, P Sini, G Nieddu… - Cell death & …, 2020 - nature.com
… deacetylase 1 (HDAC1) via RRM1 and RRM2 domains, that … with pan-HDAC inhibitors exert
a protective role against WT or … transferase) activity of CBP (CREB binding-protein). Once …

[HTML][HTML] … inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS …

R Kuta, N Larochelle, M Fernandez, A Pal… - Cell Stress and …, 2020 - Elsevier
… hallmark, and HDAC inhibition rescued the DNA repair response in iPSC-derived motor
neurons carrying the FUS P525L mutation, pointing to multiple mechanisms of neuroprotection

Whole and fractionated human platelet lysate biomaterials-based biotherapy induces strong neuroprotection in experimental models of amyotrophic lateral sclerosis

F Gouel, K Timmerman, P Gosset, C Raoul, M Dutheil… - Biomaterials, 2022 - Elsevier
… could exert synergistic functional and neuroprotective … Therefore, HHPL confers
neuroprotective effect against both … HHPL could be neuroprotective in an in vivo severe model of …

A therapeutic perspective of HDAC8 in different diseases: an overview of selective inhibitors

A Fontana, I Cursaro, G Carullo, S Gemma… - International Journal of …, 2022 - mdpi.com
… dissemination of breast cancer cells in vitro and in vivo, through the activation of EMT, a …
activity was proven to exert a neuroprotective effect [10]. Neuroprotection derives from the …

Synergistic association of resveratrol and histone deacetylase inhibitors as treatment in amyotrophic lateral sclerosis

E Parrella, V Porrini, I Scambi, MM Gennari… - Frontiers in …, 2022 - frontiersin.org
… In vivo, oral administration of VPA at the antiepileptic dose of approximately 500 mg/kg/day
increased lifespan by 8% without delaying the disease onset in SOD1(G93A) male mice (…

[PDF][PDF] Trace element, antioxidant and oxidant levels in spinal cord injury: different perspective on the effects of valproic acid.

M Ulas, OG Argadal - European Review for Medical & …, 2023 - europeanreview.org
Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent
mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse …