Histone deacetylases inhibitors in neurodegenerative diseases, neuroprotection and neuronal differentiation
S Shukla, BL Tekwani - Frontiers in pharmacology, 2020 - frontiersin.org
… The global co-activator includes p300 and CREB binding Protein. Nuclear receptor co-…
in neuronal differentiation and neuroprotection in different cell lines, in vivo preclinical animal …
in neuronal differentiation and neuroprotection in different cell lines, in vivo preclinical animal …
Beneficial and sexually dimorphic response to combined HDAC inhibitor valproate and AMPK/SIRT1 pathway activator resveratrol in the treatment of ALS mice
O Bankole, I Scambi, E Parrella, M Muccilli… - International Journal of …, 2022 - mdpi.com
… effect was associated with an overall neuroprotective effect … -apoptotic effect by upregulating
Bcl-xL expression in vivo [48]… beneficial role in ALS, exerting both neuroprotective and anti-…
Bcl-xL expression in vivo [48]… beneficial role in ALS, exerting both neuroprotective and anti-…
[HTML][HTML] Therapeutic potential of lithium chloride and valproic acid against neuronopathic types of mucopolysaccharidoses through induction of the autophagy process
L Gaffke, N Firyn, E Rintz, K Pierzynowska… - Archives of Biochemistry …, 2023 - Elsevier
… It can also act through autophagy induction. Similarly, some of the proposed … through which
LiCl may exert its therapeutic effects in neurodegenerative conditions include neuroprotection…
LiCl may exert its therapeutic effects in neurodegenerative conditions include neuroprotection…
Opportunities for histone deacetylase inhibition in amyotrophic lateral sclerosis
YE Klingl, D Pakravan… - British Journal of …, 2021 - Wiley Online Library
… both cultured neurons and in vivo models of neurodegeneration. Taken … In addition, it exerts
a neuroprotective role through … Due to their neuroprotective effects, valproate and lithium are …
a neuroprotective role through … Due to their neuroprotective effects, valproate and lithium are …
HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo
S Sanna, S Esposito, A Masala, P Sini, G Nieddu… - Cell death & …, 2020 - nature.com
… deacetylase 1 (HDAC1) via RRM1 and RRM2 domains, that … with pan-HDAC inhibitors exert
a protective role against WT or … transferase) activity of CBP (CREB binding-protein). Once …
a protective role against WT or … transferase) activity of CBP (CREB binding-protein). Once …
[HTML][HTML] … inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS …
R Kuta, N Larochelle, M Fernandez, A Pal… - Cell Stress and …, 2020 - Elsevier
… hallmark, and HDAC inhibition rescued the DNA repair response in iPSC-derived motor
neurons carrying the FUS P525L mutation, pointing to multiple mechanisms of neuroprotection …
neurons carrying the FUS P525L mutation, pointing to multiple mechanisms of neuroprotection …
Whole and fractionated human platelet lysate biomaterials-based biotherapy induces strong neuroprotection in experimental models of amyotrophic lateral sclerosis
… could exert synergistic functional and neuroprotective … Therefore, HHPL confers
neuroprotective effect against both … HHPL could be neuroprotective in an in vivo severe model of …
neuroprotective effect against both … HHPL could be neuroprotective in an in vivo severe model of …
A therapeutic perspective of HDAC8 in different diseases: an overview of selective inhibitors
… dissemination of breast cancer cells in vitro and in vivo, through the activation of EMT, a …
activity was proven to exert a neuroprotective effect [10]. Neuroprotection derives from the …
activity was proven to exert a neuroprotective effect [10]. Neuroprotection derives from the …
Synergistic association of resveratrol and histone deacetylase inhibitors as treatment in amyotrophic lateral sclerosis
E Parrella, V Porrini, I Scambi, MM Gennari… - Frontiers in …, 2022 - frontiersin.org
… In vivo, oral administration of VPA at the antiepileptic dose of approximately 500 mg/kg/day
increased lifespan by 8% without delaying the disease onset in SOD1(G93A) male mice (…
increased lifespan by 8% without delaying the disease onset in SOD1(G93A) male mice (…
[PDF][PDF] Trace element, antioxidant and oxidant levels in spinal cord injury: different perspective on the effects of valproic acid.
M Ulas, OG Argadal - European Review for Medical & …, 2023 - europeanreview.org
… Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent
mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse …
mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse …