[HTML][HTML] The hitchhiker guide to CD4+ T-cell depletion in lentiviral infection. a critical review of the dynamics of the CD4+ T cells in SIV and HIV infection

Q Le Hingrat, I Sereti, AL Landay, I Pandrea… - Frontiers in …, 2021 - frontiersin.org
… of the depletion of the different CD4 + T-cell subsets and their … The exceptions are strains
of SIVsab that naturally infect … membrane was abrogated, while soluble CD4 could still be …

[HTML][HTML] The role of immunomodulatory receptors in the pathogenesis of HIV infection: a therapeutic opportunity for HIV cure?

H Chen, M Moussa, M Catalfamo - Frontiers in immunology, 2020 - frontiersin.org
… , CD4 T cells are the main cell type harboring the HIV/SIV … became upregulated particularly
in different T cell subsets. In … in NK cells and myeloid cells including monocytes, dendritic cells

Soluble CD4 and low molecular weight CD4-mimetic compounds sensitize cells to be killed by anti-HIV cytotoxic immunoconjugates

…, FM Cole, HC Chen, AB Smith III, T Peters - Journal of …, 2023 - Am Soc Microbiol
different protein forms of CD4 and the small molecule CD4-… prevented by effective ART, but
the infection cannot be cured … long-lived T cells that carry a functional HIV provirus remains …

[HTML][HTML] Expansion of immature neutrophils during SIV infection is associated with their capacity to modulate T-cell function

…, B Favier, A Sáez-Cirión, R Le Grand… - Frontiers in …, 2022 - frontiersin.org
… Myeloid cells, mainly monocytes and macrophages, have … term cART, HIV-infected patients
have a higher level of soluble … neutrophil diversity in SIV infection and its impact on T-cell

[HTML][HTML] Th17 CD4+ T-cell as a preferential target for HIV reservoirs

C Renault, N Veyrenche, F Mennechet… - Frontiers in …, 2022 - frontiersin.org
SIV model to study differences in infectivity between Th17 … dendritic cells, macrophages,
monocytes, and CD4+ T cells by … Th17 CD4 T cell recovery also appears variable in the different

CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

J Harper, S Gordon, CN Chan, H Wang, E Lindemuth… - Nature medicine, 2020 - nature.com
… Due to the complexity and diversity of the CD4 + T cell … improved SIV-specific T cell responses
during chronic infection … increase in the number of monocytes (Supplementary Fig. 3d). …

[PDF][PDF] Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120

J Richard, J Prévost, C Bourassa, N Brassard… - Cell Chemical …, 2023 - cell.com
… gp120 to CD4 on the surface of monocytes, macrophages, T cells, … Three days post infection,
autologous uninfected CD4+ T cells … gp120, but our results reveal a different mode of action …

[HTML][HTML] Glycan dependent phenotype differences of HIV-1 generated from macrophage versus CD4+ T helper cell populations

EJ Heeregrave, J Thomas, TM van Capel… - Frontiers in …, 2023 - frontiersin.org
… virus (SIV) is more infectious than T cell-derived virus (30). Further… CD4 enriched lymphocytes
and monocyte derived … of cell capture and subsequent transfer to CD4 + T lymphocytes, …

[HTML][HTML] Innate, non-cytolytic CD8+ T cell-mediated suppression of HIV replication by MHC-independent inhibition of virus transcription

M Zanoni, D Palesch, C Pinacchio, M Statzu… - PLoS …, 2020 - journals.plos.org
… suppression of HIV or SIV transcription in CD4 + T cells by non-… limit HIV infection to one
replication cycle, by either blocking … CD8 + T cells, B cells and monocytes failed to suppress HIV

[HTML][HTML] Engaging innate immunity in HIV-1 cure strategies

NL Board, M Moskovljevic, F Wu, RF Siliciano… - Nature Reviews …, 2022 - nature.com
… virus (SIV) establish a latent reservoir in resting CD4 + T cells, … from ART-suppressed PLWH
reported that using monocyte-… NK cells to potently kill HIV-1-infected CD4 + T cells in diverse