… explained type 1 receptor usage, we chose a more specific … depend on ALK2 for activation
of the SMAD1/5 pathway, we … of the SMAD signaling pathway, SMAD2/3 and SMAD1/5/8, …

… of BMP type I receptor ALK2, as well as up-regulate Smad 1/5… from the immature precursor
of BMP-7 can cause osteogenic … the Smad signaling pathway can certainly produce specific …

… and TGFβ antagonist BMP7, we reasoned that ALK2 should … stimulated type I receptors and
their respective signaling pathways … Moreover, differences in TGFβ-ALK2-SMAD1/5 signaling …

… , and inhibition of these fundamental signaling pathways. … However, these other proteins
generally activate SMAD 1/5/9 in … for type II receptors by BMP6 and BMP7, generating a hybrid …

… ALK2 (Figure 4D,E). These results indicate that BMP2 activates the canonical SMAD1/5/8
signaling pathway via … However, BMP6, BMP7, or BMP15 only induced mild or no significant …

… BMP7 homodimers signal through distinct type I receptors, namely BMPR1 (also known as
ALK3) and ACVR1 (also known as ALK2, … signal through BMPR1B to activate Smad1, Smad5, …

… ; BMP5, BMP6 and BMP7 signal via ALK2, although BMP6 can also … of SMAD1, SMAD5 and
SMAD8. The TβRI/ALK5 and activin … Importantly, TGF-β/Activin and BMP signaling pathways …

… Bmp6 and Bmp7 were expressed in endothelial cells, their … of downstream targets by SMAD1/5
activation, we found that … ) signaling pathway, may be important to exert BMP signaling in …

… For example, while both BMP7 and BMP14 bind to ALK6, only BMP7 binds to ALK2 and …
signaling pathways, eight SMAD proteins have been characterized in mammals (SMAD1–8), …

… -β signaling is that the Smad signaling pathway is activated … or activated: when TGF-β1
activates the Smad1/5 pathway … expression of BMP type I receptors ALK1, ALK2, ALK3 and ALK6 […