… For the negative control either a random cell line (MDA-MB-… –antigen binding and thus cell
activation independent of high-… distance-dependent cell degranulation that occurred based on …

… and basophil-deficient transgenic mice, allowed the … an early, mast cell-independent, clinical
benefit in allergic patients. … display suppressed basophil FcεRI-mediated histamine release, …

… FcεRImediated degranulation and suppressed IL-6 and TNFα production at the transcriptional
level in mouse mast cells… as a receptor causing IgE-independent mast cell activation [264]. …

… factors by IgE dependent and independent mechanisms [17]. … tion in mice allergy model,
reduced infiltration of mast cells at … described to inhibit FcεRI-mediated mast cell degranulation. …

… -FcεRImediated mast cell activation in allergic diseases, recent studies demonstrated the
existence of an IgE-independent … mice were enriched with human mast cells, not all mast cells …

… effector functions driven by FcεRI-mediated activation. Indeed, … independent of the
phosphorylation and activation of BTK. … proteins may promote mast cell degranulation in CSU, and …

… A3 AR activation [16], was also observed in a mouse model of allergic asthma, suggesting
also the role of inosine in allergy … FcεRI-mediated degranulation in human lung, but not in skin …

… syndrome (MCAS), a condition characterized by spontaneous… mouse and data are combined
from at least two independent … in mice, with recovery to baseline expected to occur within 60…

… , commonly triggered by stimuli that involve the IgE-dependent or IgE-independent pathway…
mast cell development, but in mast cell activation. Tfe3 knock out mice show similar mast cell …

… Treatment of peanut 671 allergy and colitis in mice via the intestinal release of … allergen
and Siglec-8 ligands suppress IgE-FcεRI mediated anaphylaxis and 679 desensitize mast cells …