… 6 h in hemodialysis patients to a 27 g/24-h continuous infusion in a patient with a short PT
half-… Predicted free steady-state piperacillin troughs on 4.5 g every 6 h are displayed in Fig. 1, …

… Simulated steady-state concentrations were 1.43-times, 95%CI = (1.27; 1.61), higher in …
We could further show that prolonged and continuous infusions might be necessary for MIC …

… population pharmacokinetic analysis of CI piperacillin/tazobactam… steady-state concentration
(Css) of increasing piperacillin/tazobactam regimens (from 2.25 to 18 g daily by continuous …

… Simulations showed that continuous or extended infusion … administration to achieve appropriate
pharmacodynamic … important pharmacokinetic elements for piperacillin-tazobactam in an …

… reported with meropenem and piperacillin-tazobactam, with faster … Pharmacokinetics,
safety and tolerability of high-dose ceftobiprole medocaril administered as prolonged infusion …

… : Patients admitted to the urology ward who were treated with CI piperacillin–tazobactam or
… Average steady-state (C ss ) piperacillin–tazobactam and meropenem concentrations were …

… exposure were performed, with a median (IQR) of 2 (1–2.5) assessments per patient. Median
(IQR) piperacillin and tazobactam free steady-state concentrations (fC ss ) were 54.6 mg/L (…

… were allometrically scaled to a standardized fat-free mass of 58.2 kg [… concentrations were
predicted at steady-state. … based on patients receiving piperacillin as a continuous infusion. To …

… of an extended infusion in critically ill obese patients. However, … piperacillin/tazobactam
using Monte Carlo simulations and steady-state pharmacokinetic data from hospitalized patients…

… ill adult patients, pediatric patients, and obese patients. … Piperacillin–tazobactam has been
studied as a simulated 12 … % fT >MIC with steady-state concentrations exceeding a minimum …