… continuous infusion of piperacillin-tazobactam or meropenem is compared to intermittent bolus
administration … For example, given average steady-state plasma concentration (C ss,avg ) …

… or prolonged infusions and a steady-state concentration greater … of piperacillin/tazobactam
to improve outcome in patients … obese patients in the ICU given the large number of patients …

… ) or concentrations at steady state above 35 mg/L (when administered by continuous infusion)
… Pharmacokineticpharmacodynamic rationale for cefepime dosing regimens in intensive …

… dosed at 2 gm q8h over 3 hours, and piperacillin-tazobactam 4.5 … infusions or a steady-state
random sample for continuous … The use of a continuous infusion or prolonged infusion will …

… the volume of distribution at the steady state (V ss ) … prolonged infusions of meropenem.
The lower ISF concentrations during surgery in obese patients compared with nonobese patients …

… of malnourished adults, defined as a BMI of < 18.5 kg/m 2 [5]. … either after a single dose or
at steady state [39]. Only recently has … were administered as intermittent or prolonged infusion …

… /tazobactam Given their wide therapeutic index, β-lactam … changes also occur in cases of
morbid obesity or renal … profile can be obtained using prolonged or continuous infusion. The …

… doses with prolonged infusion of cefepime and tazobactam in a … In the tazobactam model
body weight on V2 and BMI on Q … Steady-state pharmacokinetics and pharmacodynamics of …

… In populations such as children, the elderly, obese patients, those … of continuous medication
> 2 days; (4) at least one steady-state … Is prolonged infusion of piperacillin/tazobactam and …

… steady state concentration (piperacillin). Accordingly, thresholds of 20 mg/L (10× ECOFF of
P. aeruginosa) and 44.5 mg/L [35] for total meropenem concentration, and thresholds of 100 …