Does prolonged infusion time really improve the efficacy of meropenem therapy? A prospective study in critically ill patients
YC Zhao, Y Zou, YW Xiao, F Wang, BK Zhang… - Infectious Diseases and …, 2022 - Springer
… In populations such as children, the elderly, obese patients, those … of continuous medication
> 2 days; (4) at least one steady-state … Is prolonged infusion of piperacillin/tazobactam and …
> 2 days; (4) at least one steady-state … Is prolonged infusion of piperacillin/tazobactam and …
Evaluation of area under the concentration–time curve-guided vancomycin dosing with or without piperacillin-tazobactam on the incidence of acute kidney injury
JD Muklewicz, TD Steuber, JD Edwards - International journal of …, 2021 - Elsevier
… Patients in the trough-guided group received vancomycin dosed to target a steady-state trough
of 15–20 mg/L, and patients … proportion of patients in the AUC-guided group were obese, …
of 15–20 mg/L, and patients … proportion of patients in the AUC-guided group were obese, …
Optimizing antimicrobial drug dosing in critically ill patients
P Póvoa, P Moniz, JG Pereira, L Coelho - Microorganisms, 2021 - mdpi.com
… continuous infusion, a steady state was achieved faster than that with discontinuous
administrations. Moreover, in polytrauma patients, achieving a steady state … in obese patients, …
administrations. Moreover, in polytrauma patients, achieving a steady state … in obese patients, …
… Induced by CAR T-Cell Treatment Have an Impact on the Pharmacokinetics of Meropenem and Piperacillin/Tazobactam in Patients with Hematological Malignancies …
C Liu, PG Cojutti, M Giannella, M Roberto, B Casadei… - Pharmaceutics, 2023 - mdpi.com
… pharmacokinetics of meropenem and/or piperacillin/tazobactam administered by continuous
infusion … assessing the meropenem or piperacillin plasma steady-state concentration (C ss )…
infusion … assessing the meropenem or piperacillin plasma steady-state concentration (C ss )…
1117. Tazobactam Pharmacokinetic/Pharmacodynamic Target Attainment in Healthy Volunteers and Critically-Ill Hospitalized Patients
… intermittent infusion and up to 4ámg/L for extended infusion, … order kinetics using near
steady-state postdistributional peak and … Aástandard high-fat/high-calorie meal had no meaningful …
steady-state postdistributional peak and … Aástandard high-fat/high-calorie meal had no meaningful …
Ensuring target concentrations of antibiotics in critically ill patients through dose adjustment
J Gorham, FS Taccone, M Hites - Expert Opinion on Drug …, 2022 - Taylor & Francis
… to either continuous infusion of piperacillin-tazobactam with TDM, … is administered as
continuous infusion, steady-state … in patients with augmented renal clearance, obesity (ie BMI > 40 …
continuous infusion, steady-state … in patients with augmented renal clearance, obesity (ie BMI > 40 …
Piperacillin/tazobactam treatment in children: evidence of subtherapeutic concentrations
P Ye, J Shi, Z Guo, X Yang, Q Li, K Chen… - … in Pharmacology, 2024 - frontiersin.org
… was collected from each patient after at least three doses of medication (at steady state). The
… Considering the current situation where continuous infusion is difficult to maintain in infants …
… Considering the current situation where continuous infusion is difficult to maintain in infants …
Pharmacokinetics and pharmacodynamics of antibiotics in cystic fibrosis: a narrative review
… in specific clinical settings (eg critically ill or obese patients). … and Vd at steady state were
higher in CF patients than in healthy … piperacillin CL was observed during continuous infusion …
higher in CF patients than in healthy … piperacillin CL was observed during continuous infusion …
Precision Drug Delivery for Vancomycin Efficacy and Safety in Critically Ill Patients
A Flannery - uknowledge.uky.edu
… (5) In order to build from the theme that continuous infusions … concentrations were assessed
at steady state, we commonly … AUC in obese patients. Empiric maintenance doses for most …
at steady state, we commonly … AUC in obese patients. Empiric maintenance doses for most …
Pharmacokinetic and pharmacodynamic optimization of antibiotic therapy in cystic fibrosis patients: current evidences, gaps in knowledge and future directions
S Magréault, C Roy, M Launay… - … Pharmacokinetics, 2021 - Springer
… continuous infusion [20] or as 3-h prolonged infusions every 6 h [25]. An observational study
found that continuous infusions of 12 g/1.5 g piperacillin/tazobactam … evaluated patients with …
found that continuous infusions of 12 g/1.5 g piperacillin/tazobactam … evaluated patients with …