… Blood samples were taken at steady state, and sampling was performed 1, 4, 6, and 8 h after
the commencement of piperacillin infusion, collected in EDTA tubes, centrifuged and stored …

… Alternative dosing regimens and modes of administration were assessed at steady state (defined
as the third day of dosing) with respect to the PTA for the three PK/PD targets. …

… Piperacillin 4 g/tazobactam 0.5 g was administered IV via a … (b) piperacillin and total (c) and
unbound (d) tazobactam … of 4.5 g of piperacillin/tazobactam at steady-state conditions before …

… treatment data (dosing at baseline, steady-state concentrations [C ss ] at first TDM-guided
ECPA, average meropenem or piperacillin-tazobactam C ss during treatment course in …

… timely antimicrobial administration, but also on dose-regimen optimization to achieve
optimal pharmacokinetic (PK)/pharmacodynamic (PD) targets associated with maximal efficacy. …

… or piperacillin/tazobactam were included. PK samples were collected at a steady state …
Piperacillin/tazobactam was administered intravenously at a dose of 80 mg/kg/10 mg/kg or …

… Patients receiving the lowest ceftolozane/tazobactam regimen needed to receive six doses
to achieve steady-state plasma concentrations, while for all other patients the number of …

… Caution should be taken when combining vancomycin … a steady-state trough of 15–20
mg/L, and patients in the AUC-guided group received vancomycin dosed to target a steady-state …

… administering piperacillin may seem a better method over intermittent administration, where
… suffice to rapidly reach concentrations above the desired steady-state concentration (Fig. 4). …

… steady state concentrations were higher than steady state concentrations as 45% of these
samples were taken … ward (where TZP/MEM is given as an extended infusion with a loading …