… A single blood sample was taken from the participant at the end of a dosing interval (trough)
at steady-state (defined as >24 h after initiation of therapy). Total (n = 79) or unbound (n = 19…

… period, usually exceeding the span of piperacillin/tazobactam administration. … ) and T lag
after the first dose and at steady state. At steady state, T lag was not significantly different from …

… given dosing interval, allowing enhanced bacterial killing 80 . Roberts et al., demonstrated
median steady-state … study, the sampling was performed at steady state in the CI arm) 108 . …

… whether the pharmacokinetics of meropenem and/or piperacillin/tazobactam administered by
… , by assessing the meropenem or piperacillin plasma steady-state concentration (C ss ). At …

… piperacillin CL was observed during continuous infusion than during intermittent infusion:
piperacillin steady-state … Piperacillin-tazobactam is commonly administered through venous …

… , piperacillin-tazobactam and meropenem) by continuous infusion (CI), a steady state …
Ceftolozane-tazobactam administration by extended infusion was shown to prevent MIC …

… Participants provided a minimum of two and a maximum of eight samples at steady-state (after
four half-lives, as determined from the summary of product characteristics). Sampling …

… The term pharmacokinetic refers to the study of concentration changes of a drug over a given
… is recommended to achieve an effective steady-state concentration by day 3 of treatment. …

… tazobactam ELF concentrations were measurable at 8 hours post-administration (ie trough).
… In patients with suspected or confirmed VAP, the cefiderocol steady-state C ELF /fC s was …

… Ceftazidime and avibactam concentrations were measured at steady-state and the free fraction
… Our findings suggest that in this scenario administering ceftazidime-avibactam by CI may …