… This Cys-loop family includes the nicotinic acetylcholine receptors (nAChRs), serotonin type
3 receptors (5-… A (α9) 2 (α10) 3 stoichiometry has been determined for the rat recombinant …

… (A) Side sectional view of the α9α10 nAChR (brown and teal) structure embedded in the cell
membrane (blue). (B,C) Top view of the α9α10 nAChR structure in different stoichiometries. …

… This PhD thesis focuses on the study of the α4β2 nicotinic acetylcholine receptors (nAChRs).
This dissertation is divided into two parts. The first part is centred on the design, synthesis, …

… of α9α10 nAChRs to choline, the metabolite of acetylcholine … α9α10 receptors it is a partial
agonist of the rat receptor. Making use of the expression of α9α10 heterologous receptors, …

α-Conotoxins (α-CTxs) can selectively target nicotinic acetylcholine receptors (nAChRs) and
are important drug leads for the treatment of cancer, chronic pain, and neuralgia. Here, we …

… ear hair cell α9α10 nicotinic acetylcholine receptors (nAChRs) … The rational for targeting
this receptor is based on the fact … Alternate stoichiometries have been reported for this receptor…

… Interestingly, in comparison to the monomer peptide, RgIA# dimer exhibited α9α10 subunit
stoichiometric-dependent sensitivity (Supporting Information, Figure S4 and Table S2). In our …

… selective antagonists for either α7 or α9α10 receptors, respectively. While the downregulation
… receptors with the subunit stoichiometry α4(2)β2(3), (34) low sensitivity α4β2 (α4(3)β2(2)) …

… synapse involves α9α10 nicotinic acetylcholine receptors (… assembly and surface expression
of α9α10 require ligand binding. … postsynaptic α9α10 function and abnormally retain α9α10-…

… α9α10 nAChRs and a new motif for designing potent inhibitors against α9α10 nAChRs. …
This work provides a novel conotoxin potently targeting α9α10 nAChRs and a new motif to …