… a strategy that has already had success. The purpose of this manuscript is to review the role
of cAMP and PKA signaling … opportunities for targeting cAMP signaling in ADPKD have not …

… for many other diseases (35% of all approved drugs target G-… overview of general GPCR
signaling; the function of polycystin-1 (… and cAMP signaling; the cross-talk of calcium and cAMP …

… signaling pathways in PKD and renal receptors that can be potential targets of peptide-mediated
strategies… reduce pathways downstream of cAMP in a polycystic kidney disease rat (PCK…

… cAMP]i to slow cyst growth and delay loss of kidney function, has been recently approved as
the first disease-modifier drug for treatment of ADPKD … in experimental studies of ADPKD [11,…

… cAMP level, and a reduction of mechanistic target of … treatment did. The rationale in this
approach is that a combination of drugs targeting simultaneously the complex signaling in ADPKD…

… of polycystic kidney disease. While surgery has been the mainstay in … While drugs that
target cAMP, mTOR and bile acids were … strategies currently available for renal cystogenesis. …

… cAMP functions in cellular signalling processes that control … kidney functions and which
play a role in kidney diseases, … cAMP signalling compartments may lead to novel strategies …

… Drug repurposing is a strategy for identifying new clinical … several ADPKD animal models
by inhibiting cAMP signaling and … targets of autosomal dominant polycystic kidney disease are …

… cAMP as a driver of fluid secretion into the cysts in ADPKD … , inhibit cAMP-activated chloride
secretion by targeting CFTR in … Dietary strategies include daily caloric restriction, intermittent …

… models have suggested that cAMP signalling pathways are not … Another strategy for treating
ADPKD involves targeting the … of ADPKD, a process that is fuelled at least in part by cAMP-…