[HTML][HTML] Role of EGF receptor regulatory networks in the host response to viral infections

CR Carlin - Frontiers in cellular and infection microbiology, 2022 - frontiersin.org
… a therapeutic target in epithelial carcinomas. We will then compare what is currently known
about canonical EGFR trafficking … a potential mechanism for sustaining stress-induced EGFR

New trend in ligand-induced EGFR trafficking: A dual-mode clathrin-mediated endocytosis model

Y Zhou, H Sakurai - Journal of Proteomics, 2022 - Elsevier
… By integrating these findings on ligand- and stress-induced events, we herein propose a
dual-mode CME model in which physiological concentrations of EGF trigger the non-canonical …

Role of Virus-Induced EGFR Trafficking in Proviral Functions

SS Noh, HJ Shin - Biomolecules, 2023 - mdpi.com
… Adenovirus infection triggers the stress-induced EGFR trafficking pathway, which activates …
the EGFR/NFκB signaling pathway. Interestingly, stress-induced pathways of EGFR trafficking

[HTML][HTML] Stressinduced Rab11a‐exosomes induce amphiregulin‐mediated cetuximab resistance in colorectal cancer

JD Mason, E Marks, SJ Fan, K McCormick… - Journal of …, 2024 - ncbi.nlm.nih.gov
EGFR kinase inhibitor, we show that this effect is mediated via AREG activation of … clinically
relevant mechanism in which stressinduced Rab11a‐exosomes carrying the EGFR ligand, …

Piezo1 activates noncanonical EGFR endocytosis and signaling

C Pardo-Pastor, J Rosenblatt - Science Advances, 2023 - science.org
… shear stressinduced pY1173-EGFR internalization and … channel that includes endosomal
trafficking to the midbody during … membrane remodeling and trafficking controlling pluripotency…

Mechanism of p38 MAPK–induced EGFR endocytosis and its crosstalk with ligand-induced pathways

M Perez Verdaguer, T Zhang, JA Paulo, S Gygi… - Journal of Cell …, 2021 - rupress.org
… Endocytic trafficking of EGFR is proposed to play a key role … the mechanism of p38-dependent
endocytosis of EGFR and … pathway to the internalization of EGFR in cells stimulated with …

[HTML][HTML] Oxidative stress and signaling through EGFR and PKA pathways converge on the nuclear transport factor RanBP1

M Kodiha, N Azad, S Chu, N Crampton… - European Journal of Cell …, 2024 - Elsevier
… Nuclear protein trafficking requires the soluble transport factor RanBP1. The subcellular …
EGFR and PKA signaling pathways regulate the stress-induced nuclear accumulation of …

The endoplasmic reticulum stress and the unfolded protein response in kidney disease: Implications for vascular growth factors

CA Ricciardi, L Gnudi - Journal of Cellular and Molecular …, 2020 - Wiley Online Library
… The Golgi has a crucial function in regulating the trafficking of … morphology promoting
stress-induced mitochondrial … cell deletion of EGFR or treatment with an EGFR inhibitor resulted in …

[PDF][PDF] Dysfunctional EGFR and oxidative stress-induced PKD1 signaling drive formation of DCLK1+ pancreatic stem cells

AKF Martinez, HR Döppler, LI Bastea, B Edenfield… - Iscience, 2021 - cell.com
… the lack of efficacy of pancreatic cancer therapy. Although PanIN cells … (EGFR), we demonstrate
that, in DCLK1+ PanIN cells, EGFR … Both disturbance of vesicle trafficking and more rapid …

Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation

S Jones, PJ King, CN Antonescu, MG Sugiyama… - Scientific Reports, 2020 - nature.com
therapeutics are not fully understood but could underlie differential tumour responses. We
explored EGFR trafficking upon treatment … Sym004 promoted EGFR endocytosis distinctly from …