… To investigate the structural basis for the selective Sirt6 deacetylation of H3Kac nucleosome
substrates, we prepared nucleosomes modified with thiocarbonyl groups at the H3K9 …

… Therefore, a detailed understanding of the modulator structure and potential reactivity
with sirtuins in silico studies should precede in vitro and in vivo experiments. The latest …

… Accordingly, substrate recognition by sirtuins is affected by differences in the sirtuins’ binding
… Structural basis for sirtuin function: What we know and what we don’t. Biochim. Biophys. …

… SIRT1 is a gene that plays a role in the ageing process and age-related disorders including
early … Marmorstein, “Structural basis for sirtuin function: what we know and what we don't,” …

… the structural basis of Sirt1 inhibition by Tat, we tried to crystallize Sirt1 in complex with
Tat-Cys − and the inhibitory fragment 37–59. Since we failed to obtain a Sirt1 complex, we aimed …

… For the experimental analysis of AROS’s structure and Sirt1 modulation mechanism, we aimed
… Structural basis for sirtuin function: What we know and what we don’t. Biochim. Biophys. …

… Here, we report the identification of 23 human sirtuin isoforms, most of which were not …
Structural basis for sirtuin function: What we know and what we don’t. Biochim. Et Biophys. …

… We observe that sirtuins play a key role in a variety of biological processes and have
significant importance in … Structural basis for sirtuin function: what we know and what we don’t …

… Structural basis for sirtuin function: What we know and what we don’t. Biochimica et
Biophysica Acta, 1804(8), 1604–1616. https://doi.org/10.1016/j.bbapap.2009.09.009 …

… begins with Section I, Sirtuins and Metabolic Disease. In this section, the role of sirtuins in
metabolic disease, relation to other integral biologic pathways of sirtuins, regulation of stem …