… To get more insight into the metal coordination sphere, the … The analysis of Cu 2+ interactions
was performed in the … of Cu 2+ allowed the identification of the Cu 2+ -binding regions in …

… bioinorganic chemistry underlying the development of PD demands the understanding of the
binding specificity of Cu(II)/Cu(I… techniques to analyse the binding affinity of Cu(II) and Cu(I) …

… of α-Synuclein and its complex with two Cu(II) ions bound to experimentally determined
binding sites. Adding … The secondary structure characteristics exhibit a decrease in defined …

… of Cu(I) 4 Zn 4 MT-3 featuring an unusual redox-inert Cu(I) 4 –… effect exerted by MT-3
towards α-Syn-Cu(II). This work provides … the deleterious bioinorganic chemistry of α-Syn-Cu(II). …

… NMR to elucidate the nature of the weak binding with Ca 2+ , Zn 2+ , Cu + , Cu 2+ , and Mn
2+ . Our approach was based on a comprehensive analysis of the metal interactions by αS, …

… Cu 2+ ions impact the secondary structures of α-synuclein at an atomic level. Although the
secondary structure of α-synuclein … in LCP can provide further insight into our perception of the …

… as it could provide new insights into its development and progression … the changes in the
secondary structure characteristics. … 10 and pS129 forms of α-Synuclein, with and without Cu(II). …

… -dependent effect of Cu 2+ ions on the aggregation pathway of α-synuclein (α-Syn) proteins,
… absence of Cu 2+ ions from monomers to mature fibrils was resolved and quantified at the …

… of Cu in the α-synuclein (aS) amyloid formation process. The … , are important to study for
insights into the origin and progression … Also, the amazing improvements in structural analysis of …

… -binding compound, was able to efficiently compete with α-synuclein for both Cu(I) and Cu(II)
binding, … the pathogenesis of PD and with the fact the Cu II -ATSM is able to stimulate SOD1 …