… In this work, we provide new insights into this HDAC6i by … for its selective inhibition of HDAC6
by solving the structure of … its functional ability to enhance the levels of Ac-α-tubulin in vitro …

… We found that HDAC6-microtubule interactions are entirely independent of the catalytic domains
and are … Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. …

… HDAC6-selective inhibitors, we anticipate that indazole could serve as a good capping group
for HDAC6 inhibitors… and introduced diverse zinc-binding groups into the indazole scaffold. …

… structure determinations of HDAC6 CD2 with HDAC6i complexes provided structural and
catalytic mechanism insights into … Unlike tubulin deacetylation by HDAC6, the cortactin-HDAC6 …

… , its selective inhibition of HDAC6 blocked migration and invasion in human CRC cells. Notably,
it … , with an IC 50 value of 199 nM, and specifically upregulated tubulin acetylation levels …

… For 32 and 33, we observed a selective inhibition of the targeted enzymes Sirt2 and … To
obtain structural insights into the HDAC6 binding modes of the dual Sirt2/HDAC6 inhibitors 32 …

… inhibitor of HDAC6 PB118 in improving acetyl-α-tubulin and … evaluated their activity by the
HDACs enzyme inhibition assay … PB118 had the most selectivity toward HDAC6 enzymes and …

… promoted the acetylation of α-tubulin, resulting in microtubule … did not induce any acetylation
of α-tubulin, as expected. Taken … acetylation of α-tubulin via inhibition of HDAC6, leading to …

… the structural features and biological functions of HDAC6 and … in HDAC6 modulators, including
selective inhibitors, chimeric … Structural insights into HDAC6 tubulin deacetylation and its …

… Abnormal expression of HDAC6 gives rise to cancer, … structure and development of
HDAC6 selective inhibitors. … 47) is a dual inhibitor of HDAC6 and tubulin, and it has an …