The structure-based reaction mechanism of urease, a nickel dependent enzyme: tale of a long debate
… of the role of nickel as the essential metal ion in urease for the enzymatic catalysis of urea,
a … In 1975, jack bean urease was demonstrated to require nickel for the catalysis, providing …
a … In 1975, jack bean urease was demonstrated to require nickel for the catalysis, providing …
Urease: structure, function, catalysis, and inhibition
… This reports a nickel-bridging fluoride ion replacing the hydroxide ion present in the resting
state of the enzyme and a urea molecule replacing W1, W2, and W3 in the active site cavity …
state of the enzyme and a urea molecule replacing W1, W2, and W3 in the active site cavity …
Intrinsic disorder in the nickel-dependent urease network
… to tightly control the intracellular nickel ion quota in the cell. … in the picture of urease activation,
both the structural and … exploited by urease to efficiently regulate its catalytic mechanism …
both the structural and … exploited by urease to efficiently regulate its catalytic mechanism …
Inhibition of urease activity by different compounds provides insight into the modulation and association of bacterial nickel import and ureolysis
S Svane, JJ Sigurdarson, F Finkenwirth, T Eitinger… - Scientific reports, 2020 - nature.com
… structure and active site are surprisingly conserved among different species 2 . The active
site of urease contains two Ni 2+ ions, … 3, and as expected, the catalytic activity of JBU was …
site of urease contains two Ni 2+ ions, … 3, and as expected, the catalytic activity of JBU was …
Theoretical study on the inhibition mechanisms of heavy metal ions on urease activity
… Overall, the theoretical study provided insight into the … urease apoprotein can acquire
some activity with non-nickel … Thus, the inhibition of urease catalytic activity by heavy metals…
some activity with non-nickel … Thus, the inhibition of urease catalytic activity by heavy metals…
Moving nickel along the hydrogenase–urease maturation pathway
… structures of bacterial and plant ureases have been determined. The active site of urease
contains two nickel ions … aerogenes urease (PDB: 1FWJ)96 consists of three catalytic units. …
contains two nickel ions … aerogenes urease (PDB: 1FWJ)96 consists of three catalytic units. …
Delivering a toxic metal to the active site of urease
… Urease is a nickel (Ni) enzyme that is essential for the … pneumoniae urease contains three
catalytic units arranged … of the urease maturation pathway could provide insights into the …
catalytic units arranged … of the urease maturation pathway could provide insights into the …
Explaining urease specificity towards nickel: a re-analysis of its proposed mechanism
MP Ferreira, CB de Castro, CGCM Netto - 2020 - chemrxiv.org
… zinc ions similarly coordinated to the nickel centers in urease … , in the crystal structure of
the inhibited urease, no water … of the catalytic center is hindered, decreasing urease activity …
the inhibited urease, no water … of the catalytic center is hindered, decreasing urease activity …
QM/MM molecular dynamics simulations revealed catalytic mechanism of urease
… Urease, a nickel-containing metalloenzyme, is found in various … (14−24) It has been revealed
that two divalent nickel ions in the … mechanistic insights into the urease-catalyzed reaction. …
that two divalent nickel ions in the … mechanistic insights into the urease-catalyzed reaction. …
Urease
I D'Agostino, S Carradori - Metalloenzymes, 2024 - Elsevier
… decades, insights into the tridimensional structure of urease, its mechanism of catalysis, and
… Then, the GTP-bound UreG 2 receives the nickel ion from UreE 2 , and at this point, the new …
… Then, the GTP-bound UreG 2 receives the nickel ion from UreE 2 , and at this point, the new …