Leveraging fine-scale population structure reveals conservation in genetic effect sizes between human populations across a range of human phenotypes
… sub-Saharan African ancestry and BI+Europe (mean 11.5%) ancestry. First, local ancestry
is inferred along the phased genome, … Finally, we painted UK Biobank individuals who were …
is inferred along the phased genome, … Finally, we painted UK Biobank individuals who were …
Recent advances in polygenic scores: translation, equitability, methods and FAIR tools
… Large-scale biobanks and infrastructures are also accelerating the speed of development
and translation for PGS (eg UK Biobank), and the next generation of genomic cohorts are well-…
and translation for PGS (eg UK Biobank), and the next generation of genomic cohorts are well-…
Clinical and regulatory challenges and opportunities for monoclonal antibodies in low-and middle-income countries: Lessons from COVID-19 and beyond
L Gieber, V Muturi-Kioi, S Malhotra, A Sitlani - Pharmaceutical Medicine, 2023 - Springer
… was a phase IIb trial enrolling almost 2000 sub-Saharan … is the limited availability of
biorepository facilities, which means … the EU, with centralized and mutual recognition procedures …
biorepository facilities, which means … the EU, with centralized and mutual recognition procedures …
National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study
E Colby, S Hayward, M Benavente… - Clinical Kidney …, 2024 - academic.oup.com
… research in the UK including: a national network of research nurses for patient recruitment to
both cohorts, a centralised biorepository … in patients of recent Sub-Saharan or West African …
both cohorts, a centralised biorepository … in patients of recent Sub-Saharan or West African …
Integrating genetic variants into clinical models for hepatocellular carcinoma risk stratification in cirrhosis
P Nahon, J Bamba-Funck, R Layese, E Trépo… - Journal of …, 2023 - Elsevier
… in all participating centres and then centralised by the liver biobank of the Plateforme de …
, sub-Saharan African, or East Asian based on the closest 1,000 Genomes population in a …
, sub-Saharan African, or East Asian based on the closest 1,000 Genomes population in a …
Single-versus multi-ancestry polygenic risk scores for CKD in black Americans
AC Jones, A Patki… - Journal of the …, 2024 - journals.lww.com
… CKD with higher prevalence among those of sub-Saharan African descent—improved the
score’s … Centralized read mapping and genotype calling, along with variant quality metrics and …
score’s … Centralized read mapping and genotype calling, along with variant quality metrics and …
Oesophageal cancer in Sub-Saharan Africa: a Kenyan perspective
MM Mwachiro, RE White, MD Topazian… - South African …, 2021 - journals.co.za
… disease, provision of surgery has been centralized to generate sufficient volume to build up
… of research specimens and creating an African bio- repository for a combined genomic wide …
… of research specimens and creating an African bio- repository for a combined genomic wide …
Clinical implications of combinatorial pharmacogenomic tests based on cytochrome P450 variant selection
M Sayer, A Duche, TJT Nguyen, M Le, K Patel… - … in Genetics, 2021 - frontiersin.org
… The primary objective of this study was to evaluate the detection rate of currently available
CPGx tests based on the cytochrome P450 (CYP) gene variants they target. The detection rate …
CPGx tests based on the cytochrome P450 (CYP) gene variants they target. The detection rate …
Importance of genetic studies of cardiometabolic disease in diverse populations
L Fernández-Rhodes, KL Young, AG Lilly… - … research, 2020 - Am Heart Assoc
… For example, hypertensive heart disease has the highest burden in Central Sub-Saharan …
and phenotypic data provided by clinicians, researchers, and patients through centralized …
and phenotypic data provided by clinicians, researchers, and patients through centralized …
Public human microbiome data are dominated by highly developed countries
… regions, followed by sub-Saharan Africa, which is home to … project than someone from
sub-Saharan Africa. The 47 … outside of these large centralized repositories evaluated here…
sub-Saharan Africa. The 47 … outside of these large centralized repositories evaluated here…