The lymph node at a glance–how spatial organization optimizes the immune response

SM Grant, M Lou, L Yao, RN Germain… - Journal of cell …, 2020 - journals.biologists.com
… body that are responsible for transporting lymph, which contains … B cells and follicular dendritic
cells (FDCs), known as B cell … afferent lymphatic vessels, travels through the subcapsular

Extracellular matrix rigidity modulates physical properties of subcapsular sinus macrophage-B cell immune synapses

M Iliopoulou, AT Bajur, HCW McArthur, M Gabai… - Biophysical …, 2023 - cell.com
… the transport of antigens from lymph into lymph node follicles… of immune complex (IC)
presentation by SSMs to B cells. … by SSMs and B cells in the immune synapse. These changes …

Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift

Y Zhang, L Garcia-Ibanez, C Ulbricht, LSC Lok… - Nature …, 2022 - nature.com
… To obtain the best experience, we recommend you use a more up … seen to transport antigen,
we assumed that memory B cell … after injecting AlexFluo488 labeled immune complex at 8 d …

Lymphoid stromal cells—more than just a highway to humoral immunity

I Cinti, AE Denton - Oxford Open Immunology, 2021 - academic.oup.com
… ) to flow through the lymph node from the subcapsular sinus [17, … the lymph node increases
the pool of T and B cells inside the … antigen in the form of immune complexes, which they bind …

Compartmentalized multicellular crosstalk in lymph nodes coordinates the generation of potent cellular and humoral immune responses

J Poirot, J Medvedovic, C Trichot… - European Journal of …, 2021 - Wiley Online Library
… separated compartments: the subcapsular sinus (SSC), the … them in a complement-dependent
manner to follicular B cells … IL-6 following immune complex stimulation also contributes …

Modulating antigen availability in lymphoid organs to shape the humoral immune response to vaccines

A Aung, DJ Irvine - The Journal of Immunology, 2024 - journals.aai.org
… in draining lymph nodes, where naive T and B cells encounter Ag … (LECs) and macrophages
line the subcapsular and … Ag-conjugated synthetic particles, immune complexes (ICs), virus-…

Tingible body macrophages arise from lymph node–resident precursors and uptake B cells by dendrites

N Gurwicz, L Stoler-Barak, N Schwan… - Journal of Experimental …, 2023 - rupress.org
… the dynamics of dying GC B cell disposal remained unknown. … lymph node–resident
precursors that enter the lymph node … stationary cells that selectively phagocytose GC B cells via …

[HTML][HTML] External cues to drive B cell function towards immunotherapy

D Stoycheva, H Simsek, W Weber, AE Hauser… - Acta biomaterialia, 2021 - Elsevier
cells (DCs) [6,7] or bound in the form of immune complexes … As another mechanism
subcapsular sinus (SCS) … -dependent cell-mediated cytotoxicity, complement-dependent

B cells and cancer: To B or not to B?

WH Fridman, F Petitprez, M Meylan… - Journal of Experimental …, 2020 - rupress.org
… , or immunosuppression via immune complex formation or complement activation. However,
B cell subsets in tumors, which poses a major obstacle and dilemma when targeting B cells

Suppressing subcapsular sinus macrophages enhances transport of nanovaccines to lymph node follicles for robust humoral immunity

YN Zhang, W Poon, E Sefton, WCW Chan - ACS nano, 2020 - ACS Publications
… SCS macrophages can also capture viruses, bacteria, or immune complexes and
promote antigen transport to B cell follicles to stimulate the humoral immune responses. (2,12−17) …