The lymph node at a glance–how spatial organization optimizes the immune response
SM Grant, M Lou, L Yao, RN Germain… - Journal of cell …, 2020 - journals.biologists.com
… body that are responsible for transporting lymph, which contains … B cells and follicular dendritic
cells (FDCs), known as B cell … afferent lymphatic vessels, travels through the subcapsular …
cells (FDCs), known as B cell … afferent lymphatic vessels, travels through the subcapsular …
Extracellular matrix rigidity modulates physical properties of subcapsular sinus macrophage-B cell immune synapses
M Iliopoulou, AT Bajur, HCW McArthur, M Gabai… - Biophysical …, 2023 - cell.com
… the transport of antigens from lymph into lymph node follicles… of immune complex (IC)
presentation by SSMs to B cells. … by SSMs and B cells in the immune synapse. These changes …
presentation by SSMs to B cells. … by SSMs and B cells in the immune synapse. These changes …
Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift
Y Zhang, L Garcia-Ibanez, C Ulbricht, LSC Lok… - Nature …, 2022 - nature.com
… To obtain the best experience, we recommend you use a more up … seen to transport antigen,
we assumed that memory B cell … after injecting AlexFluo488 labeled immune complex at 8 d …
we assumed that memory B cell … after injecting AlexFluo488 labeled immune complex at 8 d …
Lymphoid stromal cells—more than just a highway to humoral immunity
I Cinti, AE Denton - Oxford Open Immunology, 2021 - academic.oup.com
… ) to flow through the lymph node from the subcapsular sinus [17, … the lymph node increases
the pool of T and B cells inside the … antigen in the form of immune complexes, which they bind …
the pool of T and B cells inside the … antigen in the form of immune complexes, which they bind …
Compartmentalized multicellular crosstalk in lymph nodes coordinates the generation of potent cellular and humoral immune responses
J Poirot, J Medvedovic, C Trichot… - European Journal of …, 2021 - Wiley Online Library
… separated compartments: the subcapsular sinus (SSC), the … them in a complement-dependent
manner to follicular B cells … IL-6 following immune complex stimulation also contributes …
manner to follicular B cells … IL-6 following immune complex stimulation also contributes …
Modulating antigen availability in lymphoid organs to shape the humoral immune response to vaccines
… in draining lymph nodes, where naive T and B cells encounter Ag … (LECs) and macrophages
line the subcapsular and … Ag-conjugated synthetic particles, immune complexes (ICs), virus-…
line the subcapsular and … Ag-conjugated synthetic particles, immune complexes (ICs), virus-…
Tingible body macrophages arise from lymph node–resident precursors and uptake B cells by dendrites
N Gurwicz, L Stoler-Barak, N Schwan… - Journal of Experimental …, 2023 - rupress.org
… the dynamics of dying GC B cell disposal remained unknown. … lymph node–resident
precursors that enter the lymph node … stationary cells that selectively phagocytose GC B cells via …
precursors that enter the lymph node … stationary cells that selectively phagocytose GC B cells via …
[HTML][HTML] External cues to drive B cell function towards immunotherapy
… cells (DCs) [6,7] or bound in the form of immune complexes … As another mechanism
subcapsular sinus (SCS) … -dependent cell-mediated cytotoxicity, complement-dependent …
subcapsular sinus (SCS) … -dependent cell-mediated cytotoxicity, complement-dependent …
B cells and cancer: To B or not to B?
… , or immunosuppression via immune complex formation or complement activation. However,
… B cell subsets in tumors, which poses a major obstacle and dilemma when targeting B cells …
… B cell subsets in tumors, which poses a major obstacle and dilemma when targeting B cells …
Suppressing subcapsular sinus macrophages enhances transport of nanovaccines to lymph node follicles for robust humoral immunity
… SCS macrophages can also capture viruses, bacteria, or immune complexes and
promote antigen transport to B cell follicles to stimulate the humoral immune responses. (2,12−17) …
promote antigen transport to B cell follicles to stimulate the humoral immune responses. (2,12−17) …