… submucosal gland (SMG) dysfunction to the proximal airway features of CF lung disease.
Studies in CF pig tracheas described secretion … are postulated to adhere to proximal CF airway …

… insults, airway submucosal glands … cystic fibrosis, stimulating submucosal glands has the
opposite effect, disrupting mucociliary transport. In cystic fibrosis (CF) pigs, loss of cystic fibrosis …

… their secretions and why they are abnormal in CF, we need … wild-type airway submucosal
glands with the cAMP-elevating … agonist carbachol activated Na + and Cl − secretion by the …

… chloride secretion, the function of epithelial sodium channel, … in the lungs and intestinal
tract of CF patients. Understanding … in the submucosal glands of airways in CF patients when …

… secretion in CF airway secretory cells but not in ciliated cells. … the coexpression of all epithelial
sodium channel subunits in … Airway submucosal glands from cystic fibrosis swine suffer …

… airway epithelia (Figure E2A). MUC5AC protein was not detected in the submucosal glands
of the … between active airway transepithelial Na + absorption versus Cl − secretion that would …

… secretion to the submucosal glands (SMGs) of the proximal … levels of ENaC and cystic fibrosis
transmembrane conductance … airway surfaces thus can reflect an absolute increase of Na + …

… including anion secretion and Na + … from submucosal glands contributes to the disruption
of mucociliary transport (97). This failure of detachment occurs due to reduced anion secretion …

… Reitz, JJ Wine, AS Verkman, Submucosal gland secretions in airways from cystic fibrosis
patients have normal [Na(+)] and pH but elevated viscosity. Proceedings of the National …

… by the dysfunction of the cystic fibrosis transmembrane conductance … secretion by comparing
the proximal and distal airways, as well as the superficial epithelia and submucosal glands (…