Integrating the roles of midbrain dopamine circuits in behavior and neuropsychiatric disease

APF Chen, L Chen, TA Kim, Q Xiong - Biomedicines, 2021 - mdpi.com
… not predict habit suppression, and both … rewarding effects induced by drugs [171]. From the
pharmacological manipulations, we can see that the dopaminergic system is again mediating

Continuous cholinergic-dopaminergic updating in the nucleus accumbens underlies approaches to reward-predicting cues

M Skirzewski, O Princz-Lebel… - Nature …, 2022 - nature.com
… suggest that CIN-mediated pausing of tonic ACh release during rewards may underlie the
… These results suggest that in mice with low levels of VAChT, presynaptic-mediated plasticity …

An inhibitory brainstem input to dopamine neurons encodes nicotine aversion

C Liu, AJ Tose, JPH Verharen, Y Zhu, LW Tang… - Neuron, 2022 - cell.com
… the rewarding dose of … neurons by aversive nicotine is mediated by a7Rs, which makes this
neural population a candidate for the inhibitory input in our model that drives the suppression

A proposed role for glucocorticoids in mediating dopamine-dependent cue-reward learning

SA Lopez, SB Flagel - Stress, 2021 - Taylor & Francis
dopamine interact to mediate individual differences in reward-… reward learning associated
with psychopathology. Specifically, we propose that glucocorticoids are involved in dopamine-…

Dopamine neurons gate the intersection of cocaine use, decision making, and impulsivity

TJ Hynes, KM Hrelja, BA Hathaway… - Addiction …, 2021 - Wiley Online Library
… Cue- and cocaine-induced suppression of dopamine may lead to reward-deficient states …
we observe here may be mediate by activity of dopamine in both the striatum and the mPFC. …

A putative loop connection between VTA dopamine neurons and nucleus accumbens encodes positive valence to compensate for hunger

X Cui, Q Tong, H Xu, C Xie, L Xiao - Progress in Neurobiology, 2023 - Elsevier
… Endogenous glucagon-like peptide-1 (GLP-1) reduces food intake by suppressing the …
DA neurons may activate the reward-excited neurons in the medial NAc to promote reward and …

Pituitary adenylate cyclase activating polypeptide inhibits A10 dopamine neurons and suppresses the binge-like consumption of palatable food

N Le, J Hernandez, C Gastelum, L Perez, I Vahrson… - Neuroscience, 2021 - Elsevier
… feeding and reward/addiction that involves the mesolimbic dopamine (… neurons inhibit
A 10 dopamine neurons within the hedonic energy balance circuitry via PAC1 receptor-mediated

Neurotensin in reward processes

ML Torruella-Suárez, ZA McElligott - Neuropharmacology, 2020 - Elsevier
reward-related behaviors, although whether this effect is mediated through downstream
dopamine … the role of NTS LH neurons in feeding suppression to signaling through NTSR1, …

From prediction to action: dissociable roles of ventral tegmental area and substantia nigra dopamine neurons in instrumental reinforcement

KM Fraser, HJ Pribut, PH Janak… - Journal of …, 2023 - Soc Neuroscience
… actions they can emit to earn reward. While rats will avidly … calculated for each subject a
suppression ratio, defined here … learning-mediated temporal backpropagation of the dopamine

The interpeduncular-ventral hippocampus pathway mediates active stress coping and natural reward

Y Sherafat, M Bautista, JP Fowler, E Chen, A Ahmed… - ENeuro, 2020 - eneuro.org
… been well established that serotonergic signaling mediates various aspects of these maladaptive
… associated with coping strategies and natural reward. Specifically, inhibition of the IPN-…