… reward and motivation related information, and project intensively to midbrain dopamine
neurons, … RMTg-SNc pathway suppressed the firing rate of SNc putative dopamine neurons. (A) …

… striatal function and underlies various reward, attention, and … and dopaminergic midbrain
afferents in mediating polysynaptic … mediated by dopaminergic axons, it is strongly suppressed …

… -mediated regulation of stress and the brain's reward … area, with dopamine neurons
predominantly projecting to the … This interaction culminates in the suppression or blockade of …

… PVT→NAc-mediated behavioral inhibition, despite systemic or intra-NAc opioid administration.
Overall, we discover a keystone neuronal system for the suppression of reward-motivated …

… -mediated long-term depression in LHb neurons. Moreover, … and reward prediction errors
through suppression of VTA … LTD at GABAergic synapses onto VTA dopamine neurons 29 . The …

… in dopamine neuron firing in responses to unexpected rewards before the … mediated by
D2R-SPNs allows for discrimination learning that suppresses generalized responses mediated …

… or D2 Neurons Increases Unproductive Reward Seeking We … neuron activity would interfere
with behavioral suppression, … neurons appears to be critical for NAc-mediated suppression …

… behavioral data demonstrated that removal of the aversive state … reward. Accumulating
evidence suggests that midbrain … demonstrated that VTA dopaminergic neurons were also found …

… that regulate distinct facets of reward processing. VTA … Thus, Gαo mediates a substantial
fraction of somatodendritic … -like alcohol consumption is also suppressed in constitutive RGS6 À/…

… reward, feeding and locomotion. Since not all midbrain LepR mediated behaviors can be
explained by LepR neurons … these LepR neurons to contribute to the suppression of motivation, …