… indicated abnormal synaptic plasticity … synaptic plasticity, including synaptic structure,
synaptic plasticity-related genes, neuroplasticity, synaptic transmission, and cognitive dysfunction …

… pathophysiology is widespread synaptic dysfunction and loss, … However, understanding the
initiation of synaptic dysfunction … do not fully explain the synaptic alterations or the behavioral …

… synaptic development and function. These data provide strong support for the view that synaptic
dysfunction … is a central component of schizophrenia pathophysiology. Implicated genes …

… Thus, we propose a multi-hit model, with both early and late risk factors converging to lead
to synapse dysfunction and aberrant glial-mediated synaptic pruning. As microglia show …

… as structural modifications of excitatory synapses, are critically … ultrastructural changes in
synapses in schizophrenia and autism … in the light of findings in regular synaptic physiology. …

… Glutamate dynamics at the tripartite synapse include … tripartite synapse in schizophrenia-related
cognitive dysfunction. … Next, we delve into glutamate tripartite synaptic components and …

… (the same structure where increased pre-synaptic release of dopamine has been reported …
; and pre-synaptic modulation of glutamatergic release (as single agents for acute psychosis). …

… synapses. More SCZ risk genes were identified within the modules of PSD/trans-synaptic …
need to be further explored in future studies assessing the relation to synapse dysfunction. …

… synaptic pruning may be only one of many mechanisms underlying what we call schizophrenia…
The etiopathology of schizophrenia and related disorders is best conquered piecemeal (ie…

… lead to an improved understanding of glutamate signaling dysfunction in schizophrenia. …
in patients with schizophrenia. To test our hypothesis, we isolated post-synaptic fractions (PSF) …