Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis
CS Yadavalli, S Upparahalli Venkateshaiah… - Communications …, 2023 - nature.com
… prevent tissue destruction in NLRP3-related allergic diseases in experimental models 21 ,
and … IL-18-mediated EoE pathogenesis. Thus, we first examined the expression of NLRP3 and …
and … IL-18-mediated EoE pathogenesis. Thus, we first examined the expression of NLRP3 and …
Macrophages-induced IL-18–mediated eosinophilia promotes characteristics of pancreatic malignancy
HK Kandikattu, M Manohar, AK Verma… - Life Science …, 2021 - life-science-alliance.org
… that NLRP3-IL-18–induced eosinophils accumulate near the … on the role of IL-18–induced
eosinophilia in the development of PC … IL-18 and our presented improved CP pathogenesis is …
eosinophilia in the development of PC … IL-18 and our presented improved CP pathogenesis is …
[HTML][HTML] Insight into IL-5 as a Potential Target for the Treatment of Allergic Diseases
K Antosz, J Batko, M Błażejewska, A Gawor, J Sleziak… - Biomedicines, 2024 - mdpi.com
… Interleukin-5 functions as a B-cell differentiation factor, but … for mediating IL-5-induced effects
in both eosinophils and B … applications of IL-5 inhibition in eosinophilic asthma difficult-to-…
in both eosinophils and B … applications of IL-5 inhibition in eosinophilic asthma difficult-to-…
Eosinophils in the pathogenesis of pancreatic disorders
M Manohar, HK Kandikattu… - Seminars in …, 2021 - Springer
… Development of eosinophils from bone marrow upon allergen or antigen … the synergistic
effects of interleukin (IL)-5 and IL-18 in eosinophil-mediated pathogenesis of allergic diseases. …
effects of interleukin (IL)-5 and IL-18 in eosinophil-mediated pathogenesis of allergic diseases. …
Allergens induce upregulated IL-18 and IL-18Rα expression in blood Th2 and Th17 cells of patients with allergic asthma
J Wang, M Zhan, Y Zhai, S Wang, F Gu… - Clinical and …, 2024 - academic.oup.com
… Interleukin (IL)-18 acts as an inducer of Th2 and Th17 cell responses. However, …
overexpression of IL-18 and the synergy of IL-5 and IL-18 in eosinophils facilitate allergic disorders …
overexpression of IL-18 and the synergy of IL-5 and IL-18 in eosinophils facilitate allergic disorders …
Role of IL‐18‐transformed CD274‐expressing eosinophils in promoting airway obstruction in experimental asthma
… the role of IL-18 in asthma and allergic diseases; however, … mexicana-mediated infection,
and reduced airway hyperactivity. … the synergy of IL-18 and IL-5-induced eosinophilia in allergic …
and reduced airway hyperactivity. … the synergy of IL-18 and IL-5-induced eosinophilia in allergic …
The immunomodulatory potentials of interleukin‐27 in airway allergies
A Jafarzadeh, M Nemati, S Jafarzadeh… - Scandinavian …, 2021 - Wiley Online Library
… The IL-5-Eotaxin synergy enhances lung and circulatory … -18-induced IFN-γ production by
NK cells 59 (Figure 2). The … B cells to secrete antibody aggravating allergic disorders. Th2-cell-…
NK cells 59 (Figure 2). The … B cells to secrete antibody aggravating allergic disorders. Th2-cell-…
Allergens elicit upregulated IL‐18 and IL‐18Rα expression in blood monocytes of patients with allergic rhinitis
J Wang, F Gu, Z Li, M Zhan, L Wang… - Scandinavian …, 2022 - Wiley Online Library
… Interleukin (IL)-18 is a potentially important molecule in … A pathologic role for IL-18 in the
induction of allergic diseases … that synergy of IL-5 and IL-18 in eosinophils mediated the …
induction of allergic diseases … that synergy of IL-5 and IL-18 in eosinophils mediated the …
To evaluate the role and relevance of cytokines IL-17, IL-18, IL-23 and TNF-α and their correlation with Disease Severity in Chronic Urticaria
P Sharma, PK Sharma, A Chitkara… - Indian dermatology …, 2020 - journals.lww.com
… interleukin-17 (IL-17), interleukin-18(IL-18), interleukin-23(IL-… [ 1 2 3 ] The basic event in the
pathogenesis of urticaria is … The released cellular contents mediate the immediate phase of …
pathogenesis of urticaria is … The released cellular contents mediate the immediate phase of …
Mechanistic insights into eosinophilic esophagitis: therapies targeting pathophysiological mechanisms
… The effect of IL-25 on several allergy disorders has now … Lastly, its synergistic action with
TGF-β1 can activate quiescent … IL-18 belongs to the IL-1 family, a pleiotropic cytokine produced …
TGF-β1 can activate quiescent … IL-18 belongs to the IL-1 family, a pleiotropic cytokine produced …