Discovery of Novel Dihydropyrimidine and hydroxamic acid hybrids as potent Helicobacter pylori Urease inhibitors

R Mamidala, SRS Bhimathati, A Vema - Bioorganic Chemistry, 2021 - Elsevier
Kinetic studies revealed that a mixed inhibition with both … , we synthesized two series of
DHPM based hydroxamic acids … by molecular docking studies wherein the hydroxamic acid

Synergizing structure and function: Cinnamoyl hydroxamic acids as potent urease inhibitors

LPS Viana, GM Naves, IG Medeiros, AS Guimarães… - Bioorganic …, 2024 - Elsevier
… Among ureolytic pathogenic bacteria, Helicobacter pylori is of … , we synthesized and evaluated
the ureolytic properties of a … acids 4a, 4e, 4i, and 4k on the kinetics of type III urease from …

Insights into the design of inhibitors of the urease enzyme-a major target for the treatment of Helicobacter pylori infections

AT Fiori-Duarte, RP Rodrigues… - Current Medicinal …, 2020 - ingentaconnect.com
… , including natural, synthetic and semisynthetic products … kinetics describe a competitive
inhibition profile for compound 58 and a noncompetitive profile for 60, while molecular docking

An overview on the synthetic urease inhibitors with structure-activity relationship and molecular docking

W Yang, Q Feng, Z Peng, G Wang - European Journal of Medicinal …, 2022 - Elsevier
kinetics, structure-activity relationship, and molecular docking. The … by Helicobacter pylori
infection through inhibiting urease … of β-hydroxy-β-phenylpropionyl hydroxamic acid 20 were …

Computational Strategies Targeting Inhibition of Helicobacter pylori and Cryptococcus neoformans Ureases

M Fabris, NM Nascimento-Júnior… - Current …, 2023 - ingentaconnect.com
… Enzyme kinetic studies revealed that this compound … Based on the above considerations,
molecular docking is a … from novel oxoindoline derivatives: Synthesis, biological evaluation and …

In vitro Anti-Helicobacter pylori, Anti-urease and Anti-gastric Cancer Activities of Novel Hydrazones

Z Maryam, B Kaya, HE Bostancı, D Kısa, İ Çelik… - Journal of Molecular …, 2024 - Elsevier
… In this study, new hydrazone derivatives were synthesized by … Molecular docking assessments
on the most potent derivatives were also performed to determine the mode of inhibition. …

Synthesis and structure-activity relationship studies of N-monosubstituted aroylthioureas as urease inhibitors

…, ZJ Fu, WY Zhu, K Li, F Li, X Zou, H Ouyang… - Medicinal …, 2021 - ingentaconnect.com
Synthesis, molecular docking and biological evaluation of 3-arylfuran-2(5H)-ones as anti-…
nitidum against Helicobacter pylori urease and jack bean urease: Kinetics and mechanism. J. …

Design and discovery of urease and Helicobacter pylori inhibitors based on benzofuran/benzothiophene-sulfonate and sulfamate scaffolds for the treatment of …

O Hashem, S Zaib, SO Zaraei, H Javed… - International Journal of …, 2024 - Elsevier
… subjected to molecular docking to analyze the ligand-protein … of inhibition of urease was
determined by enzyme kinetics … The synthetic inhibitors were subjected to urease docking

Recent efforts in the discovery of urease inhibitor identifications

WQ Song, ML Liu, SY Li, ZP Xiao - Current Topics in Medicinal …, 2022 - ingentaconnect.com
… pathogens such as Helicobacter pylori, Proteus mirabilis, and … Kinetics study disclosed the
competitive or mixed inhibition … evaluation and molecular docking of protocatechuic acid from …

Urease

I D'Agostino, S Carradori - Metalloenzymes, 2024 - Elsevier
… diagnostic kits for Helicobacter pylori infectious diseases and … Kinetic studies revealed a
noncompetitive inhibition, while in … Molecular docking simulations revealed a good fitting into …