[HTML][HTML] Synthesis of 2, 7-diarylpyrazolo [1, 5-a] pyrimidine derivatives with antitumor activity. Theoretical identification of targets
A Ballesteros-Casallas, M Paulino, P Vidossich… - European Journal of …, 2022 - Elsevier
… pyrazolo[1,5-a]pyrimidine ring system constitutes a privileged scaffold for developing drug-like
compounds, whose biologic activity … synthesis of nine 2,7-diarylpyrazolo[1,5-a]pyrimidine …
compounds, whose biologic activity … synthesis of nine 2,7-diarylpyrazolo[1,5-a]pyrimidine …
Synthesis and in-vitro anti-proliferative evaluation of some pyrazolo [1, 5-a] pyrimidines as novel larotrectinib analogs
… substrates in the synthesis of several biologically active heterocyclic compounds and drug
intermediates, were chosen in this study for the synthesis of pyrazolo[1,5-a]pyrimidines 11a–j. …
intermediates, were chosen in this study for the synthesis of pyrazolo[1,5-a]pyrimidines 11a–j. …
Design, synthesis and antitumor evaluation of novel 5-methylpyrazolo [1, 5-a] pyrimidine derivatives as potential c-Met inhibitors
G Luo, Y Ma, X Liang, G Xie, Y Luo, D Zha, S Wang… - Bioorganic …, 2020 - Elsevier
… anti-tumor activities [18], [19], [20], [21], [22], [23], [24]. Furthermore, as a pharmacophore, the
similar structural features between the pyrazolo[1,5-a]pyrimidine … as pyridine and pyrimidine…
similar structural features between the pyrazolo[1,5-a]pyrimidine … as pyridine and pyrimidine…
Development of pyrazolo [1, 5-a] pyrimidine derivatives: Synthesis, anticancer activity and docking study
OM Elbakry, MF Harras, MM Elsebaei… - … and Medical Sciences, 2024 - journals.ekb.eg
… for the discovery of novel antitumor agents 12,13. Pyrazolo[1,5-a]pyrimidines (PP) are a …
In this research, we have developed new derivatives having the pyrazolo[1,5-a]pyrimidine …
In this research, we have developed new derivatives having the pyrazolo[1,5-a]pyrimidine …
[HTML][HTML] New Oxazolo[5,4-d]pyrimidines as Potential Anticancer Agents: Their Design, Synthesis, and In Vitro Biological Activity Research
A Sochacka-Ćwikła, M Mączyński… - International Journal of …, 2022 - mdpi.com
… In this work, novel oxazolo[5,4-d]pyrimidine derivatives were designed, synthesized, and
evaluated in vitro for their cytotoxic activity against a panel of four human cancer cell lines (lung …
evaluated in vitro for their cytotoxic activity against a panel of four human cancer cell lines (lung …
Synthesis, Molecular Docking Studies and ADME Properties of Some New Pyrazolo [1, 5-a] pyrimidines as Antimicrobial, and Anticancer Agents
… activity of pyrazolo[1,5-a]pyrimidines [24, 25] and pyrazolo[3,4-b]pyridines [26, 27], we aimed
herein, to synthesize … antitumor activity when compared with cisplatin (Table 2). From IC50 …
herein, to synthesize … antitumor activity when compared with cisplatin (Table 2). From IC50 …
Synthesis and anticancer activity of some fused heterocyclic compounds containing pyrazole ring
AY Hassan, MA Mohamed, A Abdel-Aziem… - Polycyclic Aromatic …, 2020 - Taylor & Francis
… ring fused to pyrimidine, pyridine and imidazole rings are of … 1 Pyrazolopyrimidines
exhibited various biological activities … have devised an efficient synthesis for pyrazolo[3,4-d]pyridine-6(…
exhibited various biological activities … have devised an efficient synthesis for pyrazolo[3,4-d]pyridine-6(…
New Potential Antitumor Pyrimidine Derivatives: Synthesis and Cytotoxicity Evaluation
GS Masaret - Polycyclic Aromatic Compounds, 2022 - Taylor & Francis
… anti-tumor activity of the prepared compounds (listed in Table 1 ) against different tumor cell
lines (listed in Table 1 ). … The present study describes the synthesis and antitumor activity of a …
lines (listed in Table 1 ). … The present study describes the synthesis and antitumor activity of a …
Synthesis and biological evaluation of aryl derivatives of isoxazole pyrazolo [1, 5-a] pyrimidines as anticancer agents
DN Bhogireddy, SR Surapureddi, T Syed… - Synthetic …, 2022 - Taylor & Francis
… A new library of different substituted aryl derivatives of isoxazole-pyrazolo[1,5-a]pyrimidine
(10a–j) were prepared, confirmed their structures by 1 HNMR, 13 CNMR and mass spectral …
(10a–j) were prepared, confirmed their structures by 1 HNMR, 13 CNMR and mass spectral …
Synthesis of a new series of pyrazolo [1, 5-a] pyrimidines as CDK2 inhibitors and anti-leukemia
… Finally, the pyridine oxide moiety is partially exposed to the … , this work was devoted to design
a new group of small … For anti-tumor activity, substitution of the phenyl ring R with halogen …
a new group of small … For anti-tumor activity, substitution of the phenyl ring R with halogen …