Design, synthesis and biological evaluation of some new 2-Pyrazoline derivatives as potential anticancer agents
… pyrazole and pyrazoline derivatives. In this study, we aimed the synthesis of new pyrazoline
derivatives from new chalcones and these synthesized compounds were screened potential …
derivatives from new chalcones and these synthesized compounds were screened potential …
Synthesis and biological evaluation of novel pyrazoline derivatives containing indole skeleton as anti-cancer agents targeting topoisomerase II
Y Song, S Feng, J Feng, J Dong, K Yang, Z Liu… - European journal of …, 2020 - Elsevier
… In this work, a novel series compounds which fuse active group pyrazoline with thiochroman…
skeleton were synthesized and their antiproliferative properties were evaluated against four …
skeleton were synthesized and their antiproliferative properties were evaluated against four …
New quinoline-2-one/pyrazole derivatives; design, synthesis, molecular docking, anti-apoptotic evaluation, and caspase-3 inhibition assay
… We report the synthesis of new quinoline-2-one/pyrazole hybrids and their antiapoptotic
activity. This effect was studied in sight of decreasing tissue damage induced by I/R in colon of …
activity. This effect was studied in sight of decreasing tissue damage induced by I/R in colon of …
Design, synthesis and evaluation of anticancer activity of new pyrazoline derivatives by down-regulation of VEGF: Molecular docking and apoptosis inducing activity
… Furthermore, the most active pyrazoline derivative was selected to evaluate its effect on
VEGF, p-VEGFR-2 and ERK 1/2. The structure–activity relationship was discussed to determine …
VEGF, p-VEGFR-2 and ERK 1/2. The structure–activity relationship was discussed to determine …
Design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against Alzheimer's disease
… of N-aryl substituted α-aminophosphonates bearing pyrazole … synthesized solvent-free via
one-pot reaction of 1H-pyrazole-… The characterization data of synthesized novel compounds …
one-pot reaction of 1H-pyrazole-… The characterization data of synthesized novel compounds …
New chalcone-type compounds and 2-pyrazoline derivatives: Synthesis and caspase-dependent anticancer activity
… We report in this paper the synthesis and biological evaluation of new chalcone-type
compounds and 2-pyrazoline derivatives bearing a (benz)imidazole moiety. The potential …
compounds and 2-pyrazoline derivatives bearing a (benz)imidazole moiety. The potential …
[HTML][HTML] New oxadiazole and pyrazoline derivatives as anti-proliferative agents targeting EGFR-TK: design, synthesis, biological evaluation and molecular docking …
… Two new series of oxadiazole and pyrazoline derivatives were designed and synthesized
as promising EGFR-TK inhibitors. The in vitro antiproliferative activity was studied against …
as promising EGFR-TK inhibitors. The in vitro antiproliferative activity was studied against …
Recent advancements in the development of bioactive pyrazoline derivatives
… of pyrazoline derivatives have been … of novel pyrazoline derivatives which are under various
stages of clinical developments (Table 1). E−6087, also known as Enficoxib is a pyrazoline …
stages of clinical developments (Table 1). E−6087, also known as Enficoxib is a pyrazoline …
[HTML][HTML] Pyrazoline derivatives as promising novel antischistosomal agents
CS Morais, AC Mengarda, FB Miguel, KB Enes… - Scientific Reports, 2021 - nature.com
… demonstrates that pyrazoline derivatives are promising scaffolds in the discovery of novel …
In this study, a series of 17 pyrazoline derivatives were synthesized and tested in vitro on S. …
In this study, a series of 17 pyrazoline derivatives were synthesized and tested in vitro on S. …
Design, synthesis, molecular modelling and biological evaluation of novel 3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives as potent antioxidants and 15 …
… synthesis and biological evaluation of a hybrid scaffold in which 3-naphthyl pyrazole is
substituted with pyrazoline/isoxazoline ring at position 3 to generate novel and new derivatives of …
substituted with pyrazoline/isoxazoline ring at position 3 to generate novel and new derivatives of …