Design, synthesis and biological evaluation of some new 2-Pyrazoline derivatives as potential anticancer agents

F Tok, Bİ Abas, Ö Çevik, B Koçyiğit-Kaymakçıoğlu - Bioorganic Chemistry, 2020 - Elsevier
pyrazole and pyrazoline derivatives. In this study, we aimed the synthesis of new pyrazoline
derivatives from new chalcones and these synthesized compounds were screened potential …

Synthesis and biological evaluation of novel pyrazoline derivatives containing indole skeleton as anti-cancer agents targeting topoisomerase II

Y Song, S Feng, J Feng, J Dong, K Yang, Z Liu… - European journal of …, 2020 - Elsevier
… In this work, a novel series compounds which fuse active group pyrazoline with thiochroman…
skeleton were synthesized and their antiproliferative properties were evaluated against four …

New quinoline-2-one/pyrazole derivatives; design, synthesis, molecular docking, anti-apoptotic evaluation, and caspase-3 inhibition assay

AA Aly, SM Sayed, ESMN Abdelhafez… - Bioorganic …, 2020 - Elsevier
… We report the synthesis of new quinoline-2-one/pyrazole hybrids and their antiapoptotic
activity. This effect was studied in sight of decreasing tissue damage induced by I/R in colon of …

Design, synthesis and evaluation of anticancer activity of new pyrazoline derivatives by down-regulation of VEGF: Molecular docking and apoptosis inducing activity

RA Hassan, SH Emam, D Hwang, GD Kim… - Bioorganic …, 2022 - Elsevier
… Furthermore, the most active pyrazoline derivative was selected to evaluate its effect on
VEGF, p-VEGFR-2 and ERK 1/2. The structure–activity relationship was discussed to determine …

Design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against Alzheimer's disease

S Shaikh, P Dhavan, G Pavale, MMV Ramana… - Bioorganic …, 2020 - Elsevier
… of N-aryl substituted α-aminophosphonates bearing pyrazolesynthesized solvent-free via
one-pot reaction of 1H-pyrazole-… The characterization data of synthesized novel compounds …

New chalcone-type compounds and 2-pyrazoline derivatives: Synthesis and caspase-dependent anticancer activity

MI Chouiter, H Boulebd, DM Pereira… - Future Medicinal …, 2020 - Future Science
… We report in this paper the synthesis and biological evaluation of new chalcone-type
compounds and 2-pyrazoline derivatives bearing a (benz)imidazole moiety. The potential …

[HTML][HTML] New oxadiazole and pyrazoline derivatives as anti-proliferative agents targeting EGFR-TK: design, synthesis, biological evaluation and molecular docking …

MI Serag, SS Tawfik, SMI Badr, HM Eisa - Scientific Reports, 2024 - nature.com
… Two new series of oxadiazole and pyrazoline derivatives were designed and synthesized
as promising EGFR-TK inhibitors. The in vitro antiproliferative activity was studied against …

Recent advancements in the development of bioactive pyrazoline derivatives

B Nehra, S Rulhania, S Jaswal, B Kumar… - European journal of …, 2020 - Elsevier
… of pyrazoline derivatives have been … of novel pyrazoline derivatives which are under various
stages of clinical developments (Table 1). E−6087, also known as Enficoxib is a pyrazoline

[HTML][HTML] Pyrazoline derivatives as promising novel antischistosomal agents

CS Morais, AC Mengarda, FB Miguel, KB Enes… - Scientific Reports, 2021 - nature.com
… demonstrates that pyrazoline derivatives are promising scaffolds in the discovery of novel
In this study, a series of 17 pyrazoline derivatives were synthesized and tested in vitro on S. …

Design, synthesis, molecular modelling and biological evaluation of novel 3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives as potent antioxidants and 15 …

SA Ali, SM Awad, AM Said, S Mahgoub… - Journal of enzyme …, 2020 - Taylor & Francis
synthesis and biological evaluation of a hybrid scaffold in which 3-naphthyl pyrazole is
substituted with pyrazoline/isoxazoline ring at position 3 to generate novel and new derivatives of …