A multifunctional anti-AD approach: Design, synthesis, X-ray crystal structure, biological evaluation and molecular docking of chrysin derivatives
A Yang, C Liu, H Zhang, J Wu, R Shen, X Kou - European Journal of …, 2022 - Elsevier
… (1–4) were rationally designed and synthesized by the multi-target-directed … with selectivity
toward BuChE. Compound 1 as the most promising candidate exhibited the highest selective …
toward BuChE. Compound 1 as the most promising candidate exhibited the highest selective …
Broad-spectrum preclinical antitumor activity of chrysin: current trends and future perspectives
ER Moghadam, HL Ang, SE Asnaf, A Zabolian… - Biomolecules, 2020 - mdpi.com
… known as CHM-04 has been synthesized with affinity to … , chrysin is capable of reducing
STAT3 phosphorylation in … uptake of these nanoparticles and providing selective targeting. …
STAT3 phosphorylation in … uptake of these nanoparticles and providing selective targeting. …
The first chrysin-based receptor for anions recognition: Experimental investigations, DFT studies and its in vitro antitumor activity
Y Huang, D Zheng, J Bai, W Wang, Z Yang… - Journal of Molecular …, 2023 - Elsevier
… , herein we designed and synthesized a novel chrysin-linked … Phosphorylated species
are essential to storage and … , indicating that chrysin do not have any selective recognition of …
are essential to storage and … , indicating that chrysin do not have any selective recognition of …
Structure-based screening, optimization and biological evaluation of novel chrysin-based derivatives as selective PPARγ modulators for the treatment of T2DM and …
L Ma, J Tang, F Chen, Q Liu, J Huang, X Liu… - European Journal of …, 2024 - Elsevier
… of the PPARγ-Ser273 phosphorylation as well as in vitro … Such mode of action give an
efficient increase for insulin … a series of flavonoid derivatives were synthesized according to …
efficient increase for insulin … a series of flavonoid derivatives were synthesized according to …
Combined in silico and in vitro studies to identify novel antidiabetic flavonoids targeting glycogen phosphorylase
NF Brás, RPP Neves, FAA Lopes, MAS Correia… - Bioorganic …, 2021 - Elsevier
… modifications through organic synthesis approaches and … : the predominantly active
Ser14-phosphorylated R state (GPa, … ellagic acid and chrysin derivatives was assessed against …
Ser14-phosphorylated R state (GPa, … ellagic acid and chrysin derivatives was assessed against …
An In Silico and an In Vitro inhibition analysis of glycogen phosphorylase by Flavonoids, styrylchromones, and pyrazoles
S Rocha, N Aniceto, RC Guedes, HMT Albuquerque… - Nutrients, 2022 - mdpi.com
… Thus, the design of selective and effective inhibitors towards … The phosphorylated form of this
enzyme, GPa, was chosen … Flavonoid 38, chrysin, was one of the most active compounds in …
enzyme, GPa, was chosen … Flavonoid 38, chrysin, was one of the most active compounds in …
A comprehensive review on chrysin: Emphasis on molecular targets, pharmacological actions and bio-pharmaceutical aspects
A Garg, S Chaturvedi - Current drug targets, 2022 - ingentaconnect.com
… A very recent report exhibited the effectiveness of chrysin in … that chrysin induced the
prolonged ERK1/2 phosphorylation … of chrysin could be linked to a decrease in the synthesis of …
prolonged ERK1/2 phosphorylation … of chrysin could be linked to a decrease in the synthesis of …
… novel copper complexes of chrysin derivatives of organosulfur compounds based potential therapeutic agent: design, synthesis, characterization and pharmacological …
B Ebenezer, K Nagashri - 2022 - researchsquare.com
… test in mice during various assessment times (1–5 hrs). … : The Cu(II) ion may bind with the
phospho-diester bond of DNA through … A convenient and efficient copper-catalyzed synthesis of …
phospho-diester bond of DNA through … A convenient and efficient copper-catalyzed synthesis of …
pH-responsive and targeted delivery of chrysin via folic acid-functionalized mesoporous silica nanocarrier for breast cancer therapy
N Ghosh, M Kundu, S Ghosh, AK Das, S De… - International Journal of …, 2023 - Elsevier
… requirements to synthesize successful nano-DDS for chrysin, … for chrysin-mSiO 2
nanodevice-induced selective cytotoxicity … Thus, we have checked the expression of …
nanodevice-induced selective cytotoxicity … Thus, we have checked the expression of …
Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
… activity of chrysin, its various derivatives were synthesized, … ester of chrysin were obtained
by phosphorylation of –OH … C7 resulted in higher effectiveness of this chrysin analog as a …
by phosphorylation of –OH … C7 resulted in higher effectiveness of this chrysin analog as a …