Synthesis and in-vitro anti-proliferative evaluation of some pyrazolo [1, 5-a] pyrimidines as novel larotrectinib analogs

MH Attia, EZ Elrazaz, SZ El-Emam, AT Taher… - Bioorganic …, 2020 - Elsevier
… substrates in the synthesis of several biologically active heterocyclic compounds and drug
intermediates, were chosen in this study for the synthesis of pyrazolo[1,5-a]pyrimidines 11a–j. …

Synthesis, characterization, antimicrobial activity and anticancer of some new pyrazolo [1, 5-a] pyrimidines and pyrazolo [5, 1-c] 1, 2, 4-triazines

MA Hosny, YH Zaki, WA Mokbel… - Medicinal …, 2020 - ingentaconnect.com
… to the synthesis of different fused pyrazoles for medicines [26-30], Herein, we report the
synthesis of some new thiazoles and pyrazolo[1,5-a]pyrimidines and pyrazolo[5,1-c]triazine. …

Preparation of Some New Pyrazolo[1,5‐a]pyrimidines and Evaluation of Their Antioxidant, Antibacterial (MIC and ZOI) Activities, and Cytotoxic Effect on MCF‐7 Cell …

MM Vahedi, S Asghari, M Tajbakhsh… - Chemistry & …, 2023 - Wiley Online Library
… Abstract: This study aims to synthesize some novel pyrazolo[1,5-a]pyrimidine derivatives,
and investigate their biological activities. These compounds exhibited good to high antioxidant …

Synthesis, antimicrobial evaluation, molecular docking and theoretical calculations of novel pyrazolo [1, 5-a] pyrimidine derivatives

AM Fahim, AM Farag - Journal of Molecular Structure, 2020 - Elsevier
… So, the ESP of the pyrazolo[1,5-a]pyrimidine derivative 17 designate a certain point then …
to fused pyrazolo[1,5-a]pyrimidine, whereas the fused pyrazolo[1,5-a]pyrimidine contains …

Design and synthesis of certain 7-Aryl-2-Methyl-3-Substituted Pyrazolo {1, 5-a} Pyrimidines as multikinase inhibitors

MA Al-Qadhi, HA Allam, SH Fahim, TAA Yahya… - European journal of …, 2023 - Elsevier
… In designing the synthesized compounds the pyrazolo [1,5-a]pyrimidine core was kept as
a hinge binding moiety to take the place of adenine in the ATP binding pocket, then structural …

[HTML][HTML] Functional Pyrazolo[1,5-a]pyrimidines: Current Approaches in Synthetic Transformations and Uses As an Antitumor Scaffold

A Arias-Gomez, A Godoy, J Portilla - Molecules, 2021 - mdpi.com
… Likewise, the tendency of pyrazolo[1,5-a]pyrimidine derivatives to form crystals with notable
… the pyrazolo[1,5-a]pyrimidine core. At the first one, the reader will find relevant synthesis

Synthesis, molecular docking, and in silico ADME prediction of some fused pyrazolo[1,5-a]pyrimidine and pyrazole derivatives as potential antimicrobial agents

AS Hassan, NM Morsy, HM Awad, A Ragab - Journal of the Iranian …, 2022 - Springer
new bioactive pyrazolo[1,5-a]pyrimidines 14a–j and pyrazole Schiff bases 16a–j have been
designed and synthesized … The structures of new bioactive pyrazolo[1,5-a]pyrimidines 14a–j …

5-amino-3-(cyanomethyl)-1H-pyrazole-4-carbonitrile as Precursor for synthesis of some novel pyrazolo [1, 5-a] pyrimidine derivatives

MIH El-Qaliei, SAS Mousa… - Egyptian Journal of …, 2022 - ejchem.journals.ekb.eg
… for the synthesis of some new pyrazolo[1,5-a]pyrimidine derivatives … new pyrazolo[1,5-a]pyrimidine-3carbonitrile
has been synthesized and used for synthesis of new fused pyrazolo[1

[HTML][HTML] Synthesis, anticancer evaluation, and molecular modeling study of new 2-(phenylamino) pyrazolo [1, 5-a] pyrimidine analogues

OA Azher, A Hossan, RA Pashameah… - Arabian Journal of …, 2023 - Elsevier
… moiety is part of several drugs like a fused, stiff, and planar N-heterocyclic system that contains
both of pyrazole and pyrimidine moieties is known as the pyrazolo[1,5-a]pyrimidine (PP) (…

New Route to the Synthesis of Novel Pyrazolo [1, 5-a] pyrimidines and Evaluation of their Antimicrobial Activity as RNA Polymerase Inhibitors

AEM Abdallah, GH Elgemeie - Medicinal Chemistry, 2022 - ingentaconnect.com
… Aims: The current study aimed to synthesize novel pyrazolo[1,5-a]pyrimidines based on 5- …
3, a number of novel pyrazolo[1,5- a]pyrimidines were synthesized. Due to the similarity of …