[HTML][HTML] Synthetic metabolism for biohalogenation

A Cros, G Alfaro-Espinoza, A De Maria, NT Wirth… - Current opinion in …, 2022 - Elsevier
… deploying synthetic metabolism tailored for biohalogenation … selection of functional metabolic
modules that harness the … bacteria for in vivo biohalogenation. By rationally combining …

Recent advances in synthetic application and engineering of halogenases

H Minges, N Sewald - ChemCatChem, 2020 - Wiley Online Library
Biohalogenation occurs on a large variety of organic scaffolds, for … synthesis of halogenated
amino acids has been reported the first time by the group of Wendisch.109 Metabolic

Halogenases for biosynthetic pathway engineering: Toward new routes to naturals and non-naturals

BRK Menon, D Richmond, N Menon - Catalysis Reviews, 2022 - Taylor & Francis
… [Citation23] Most reported biohalogenation reactions are with … Here, we provide an
overview of synthetic biology and … control via synthetic promotors, designing metabolic division …

Intersecting xenobiology and neometabolism to bring novel chemistries to life

M Nieto‐Domínguez, PI Nikel - ChemBioChem, 2020 - Wiley Online Library
… Tryptophan is a preferred target molecule of biohalogenation pathways, and halogen … Cl,
Br and I may hinder broad applications in engineering synthetic metabolism (or, for that matter, …

Cryptic halogenation reactions in natural product biosynthesis

S Adak, BS Moore - Natural product reports, 2021 - pubs.rsc.org
… For the most part, biohalogenation reactions are metabolic endpoints in nature. That is,
however, often not the case in synthetic organic chemistry. The installment of a halogen can be a …

Macroalgal microbiomes unveil a valuable genetic resource for halogen metabolism

A Lavecchia, B Fosso, AH Engelen, S Borin, C Manzari… - Microbiome, 2024 - Springer
… Nonetheless, little is known about the metabolic … putida is a clear example of synthetic
biology [26]. This approach … related to halo- and dehalogenation metabolism, annotated using a …

Colibrimycins, Novel Halogenated Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase (PKS-NRPS) Compounds Produced by Streptomyces sp. Strain …

L Prado-Alonso, I Pérez-Victoria… - Applied and …, 2022 - Am Soc Microbiol
… -UV (UPLC-UV), high-performance liquid chromatography (HPLC)-high-resolution mass
spectrometry (HRMS), nuclear magnetic resonance (NMR), and dereplication of metabolic

Biogeochemical cycling of halogenated organic compounds in the ocean: Current progress and future directions

Y Liu, L Wang, R Liu, J Fang - Deep Sea Research Part I: Oceanographic …, 2024 - Elsevier
… , indicating the significance of HOCs metabolism in the ocean and … Studying the interplay of
processes involving the synthesis, … Biohalogenation is the principal source of natural HOCs in …

Targeted enzyme engineering unveiled unexpected patterns of halogenase stabilization

H Minges, C Schnepel, D Böttcher, MS Weiß… - …, 2020 - Wiley Online Library
… a detailed understanding of biohalogenation and provide a … and their incorporation into
metabolic pathways paves the … this synthetic methodology as an indispensable tool in synthetic

β-Dicarbonyls Facilitate Engineered Microbial Bromoform Biosynthesis

TD Loan, CE Vickers, M Ayliffe, M Luo - ACS Synthetic Biology, 2024 - ACS Publications
synthesis than a metabolic pathway, requiring high concentrations of H 2 O 2 and highly
reactive dicarbonyls for significant bromoform synthesis… Given that bromoform synthesis is …