Role of Regulatory T Cell Antigen Specificity in T Cell Tolerance, Autoimmunity, and Self-Nonself Discrimination

DE Klawon Jr - 2023 - search.proquest.com
… In a T cell reconstitution setting, selection on C4/IAb is required to prevent T cell infiltration
of … diverse array of T cells expressing T cell antigen receptors (TCRs) that recognize protein-…

Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey

MA ElTanbouly, RJ Noelle - Nature Reviews Immunology, 2021 - nature.com
… after T cell activation, where anergy and exhaustion are two … of activated T cells into
non-lymphoid tissues in mice 38,39,40 . … of antigen expression and tolerization of transgenic

Immunological Tolerance—T Cells

Y Goldfarb, C Peligero-Cruz, J Abramson - The Autoimmune Diseases, 2020 - Elsevier
… subtype (anergy, phenotype skewing), (3) prevention of T-cell … antigen-specific T-cell receptor
(TCR) transgenic mice, both … Thus naïve T cells are excluded from nonlymphoid peripheral …

The endogenous repertoire harbors self-reactive CD4+ T cell clones that adopt a follicular helper T cell-like phenotype at steady state

V Lee, DM Rodriguez, NK Ganci, S Zeng, J Ai… - Nature …, 2023 - nature.com
… that are recurrently enriched in non-lymphoid organs … cells that display hallmarks of T cell
anergy and can serve as … nT FH cells bypass central tolerance and populate the peripheral …

Emerging therapeutics for immune tolerance: tolerogenic vaccines, T cell therapy, and IL-2 therapy

CD Moorman, SJ Sohn, H Phee - Frontiers in immunology, 2021 - frontiersin.org
… infectious tolerance; therefore, we will collectively term them … and favor tolerance via the
induction of T cell anergy and … Nevertheless, preclinical studies utilizing TCR transgenic mice as …

Defining the Role of T Cell Receptor: Self-Peptide/MHC Class II Interactions in Directing CD4+ T Cell Fate, Function, and Pathogenic Potential

DM Rodriguez - 2022 - search.proquest.com
t ceLL receptor retrogenic or transgenic mice tF … for imperfect processes of centraL t ceLL
toLerance in order to avert … in vivo t ceLL anergy differ, functionaL defects of anergic cD4+ tconv …

[HTML][HTML] Cbl-b deficiency prevents functional but not phenotypic T cell anergy

TTT Nguyen, ZE Wang, L Shen… - The Journal of …, 2021 - ncbi.nlm.nih.gov
T cell anergy is an important peripheral tolerance mechanism… TCR transgenic mice, or by
adoptive transfer of TCR transgenic T … to induce anergy and are only short-term anergy models. …

The role of antigen receptor isotype in B cell development, humoral response and tolerance

V Renna - 2023 - oparu.uni-ulm.de
… Each B and T cell clone has a unique antigen receptor, … Interestingly, genetically modified
mice carrying two different … section analyzing B cell tolerance, the concept of anergy is highly …

[PDF][PDF] Molecular mechanisms leading to the emergence of mouse regulatory T lymphocytes specific to non-inherited maternal antigens

F CORAZZA - 2021 - dipot.ulb.ac.be
… perinatal T cell lineage is biased towards immune tolerance is … Tem cells are non-lymphoid
memory T cells that do not reside in … It has been reported that T cell anergic is caused by the …

[PDF][PDF] Treg-based immunotherapy for antigen-specific immune suppression and stable tolerance induction: a perspective

S Sakaguchi, R Kawakami… - Immunotherapy …, 2023 - academic.oup.com
… In addition, combining transgenic expression of an engineered receptor and FoxP3 together
… administration of antigen peptides to induce T-cell anergy via tolerogenic DCs is able to …