[HTML][HTML] N-linked glycosylation at site 158 of the HA protein of H5N6 highly pathogenic avian influenza virus is important for viral biological properties and host …
R Gao, M Gu, L Shi, K Liu, X Li, X Wang, J Hu, X Liu… - Veterinary …, 2021 - Springer
… We have shown earlier that lack of glycosylation at position 158 of the hemagglutinin (HA)
glycoprotein due to the T160A mutation is a key determinant of the dual receptor binding …
glycoprotein due to the T160A mutation is a key determinant of the dual receptor binding …
Effects of HA2 154 deglycosylation and NA V202I mutation on biological property of H5N6 subtype avian influenza virus
M Gu, Y Zhao, Z Ge, Y Li, R Gao, X Wang, J Hu… - Veterinary …, 2022 - Elsevier
… HA2 N154D mutation-induced deglycosylation and NA V202I … previously revealed that
glycosylation or not at HA1 site 158 (H3 … T160A mutation-induced deglycosylation at site 158 in …
glycosylation or not at HA1 site 158 (H3 … T160A mutation-induced deglycosylation at site 158 in …
Identification of hemagglutinin mutations caused by neuraminidase antibody pressure
F Wang, Z Wan, Y Wang, J Wu, H Fu, W Gao… - Microbiology …, 2021 - Am Soc Microbiol
… Glycosylation at site 166 (158 in H3 numbering) can enhance … In our experiment,
glycosylation at site 166 in the HA of mutant … important determinant of the hemagglutinin-neuraminidase-…
glycosylation at site 166 in the HA of mutant … important determinant of the hemagglutinin-neuraminidase-…
Phenotypic effects of substitutions within the receptor binding site of highly pathogenic avian influenza H5N1 virus observed during human infection
D Eggink, M Spronken, R van der Woude… - Journal of …, 2020 - Am Soc Microbiol
… detected within the receptor binding site of hemagglutinin of HPAI A/H5N1 … T160A substitution
to the two substitutions at positions 226 and 228, as removal of the N-glycan by the T160A …
to the two substitutions at positions 226 and 228, as removal of the N-glycan by the T160A …
Emerging of H5N6 subtype influenza virus with 129-glycosylation site on hemagglutinin in poultry in china acquires immune pressure adaption
N Xu, Y Wu, Y Chen, Y Li, Y Yin, S Chen… - Microbiology …, 2022 - Am Soc Microbiol
… with the 129-glycosylation site on hemagglutinin were the dominant strains in … 158-glycosylation
site on the HA of H5 AIVs can affect antigenicity (21, 22), and the 131-glycosylation site …
site on the HA of H5 AIVs can affect antigenicity (21, 22), and the 131-glycosylation site …
A D200N hemagglutinin substitution contributes to antigenic changes and increased replication of avian H9N2 influenza virus
… T160A mutation-induced deglycosylation at site 158 in hemagglutinin is a critical determinant
of the dual receptor binding properties of clade 2.3.4.4 H5NX subtype avian influenza …
of the dual receptor binding properties of clade 2.3.4.4 H5NX subtype avian influenza …
N-glycosylation on hemagglutinin head reveals inter-branch antigenic variability of avian influenza virus H5-subtypes
K Shi, S Feng, L Zhao, J Chen, W Song, Y Jia… - International Journal of …, 2024 - Elsevier
… of antigenic determinant clusters due to N-glycosylation at … -glycosylation sites of H1 viruses
evolved from position 158 N … of N-glycosylation at positions 133 N and 158 N (H3 numbering…
evolved from position 158 N … of N-glycosylation at positions 133 N and 158 N (H3 numbering…
N-linked glycosylation enhances hemagglutinin stability in avian H5N6 influenza virus to promote adaptation in mammals
H Sun, G Deng, H Sun, J Song, W Zhang, H Li… - PNAS …, 2022 - academic.oup.com
… of HA receptor is a critical determinant for cross-species transmission of influenza A viruses
(22). HA mutations in the RBS and loss of the glycosylation site at residue 158 in clade 2.3.…
(22). HA mutations in the RBS and loss of the glycosylation site at residue 158 in clade 2.3.…
Multiple HA substitutions in highly pathogenic avian influenza H5Nx viruses contributed to the change in the NA subtype preference
KJC Antigua, YH Baek, WS Choi, JH Jeong, EH Kim… - Virulence, 2022 - Taylor & Francis
… the glycoprotein hemagglutinin (HA) and neuraminidase (NA) … Thus, the loss of N-linked
glycosylation at N154 due to the … NA contact site also overlaps with a sialic acid-binding site. …
glycosylation at N154 due to the … NA contact site also overlaps with a sialic acid-binding site. …
… emergence of new antigen branches of H9N2 avian influenza virus in China due to antigenic drift on hemagglutinin through antibody escape at immunodominant sites
N Zhang, K Quan, Z Chen, Q Hu, M Nie… - Emerging microbes & …, 2023 - Taylor & Francis
… antigenic sites encompassed more of the 12 mutated residues we selected (Table S5). …
HI profiling analysis and screening of critical antigenic sites in H9N2 viruses. (A) Cross-HI of …
HI profiling analysis and screening of critical antigenic sites in H9N2 viruses. (A) Cross-HI of …