… TMAO accelerated the decline of kidney function and were associated with a 2.8-fold increased
mortality … whether health status affected the pooled effect value. Possible publication bias …

… -fibrotic effects of TMAO, the association between TMAO and … function, and delay the
progression of disease in CKD mice [… that TMAO is not only a biomarker of impaired renal function …

… However, data regarding TMAO and its impact on clinical outcomes are inconclusive, … that
patients with low TMAO and high CMPF had a lower risk of all-cause mortality, whereas high …

… TMAO predicted all-cause mortality in patients with chronic kidney disease (CKD) who were
candidates for renal … combined effect size of the association between mortality and TMAO. …

… , renal function-related parameters could be important confounders that influence the relationship
between TMAO and mortality in this … Similarly, to exclude the impact of these potential …

… end-stage renal disease in HF and cardiovascular mortality, is … to affect the metabolism and
immunity of host. Remarkably, … Previous study has indicated that TMAO modestly correlated …

… and, in experimental studies, has been associated with impaired kidney function and
kidney fibrosis. Given kidney clearance of TMAO, its toxic effects could be more substantial in …

… trends toward effect modification of the TMAO-mortality relationship … of TMAO with deaths
due to CVD and kidney failure were … between TMAO and renal function, renal function could be …

… diet plays a modest role in determining circulating TMAO. To … where TMAO appears to have
the biggest impact on kidney function, … the kidney, TMAO increased all-cause mortality only in …

… was only modestly correlated with TMAO levels (Spearman … and risk of mortality,
cardiovascular and renal disease in … as random effects, with baseline TMAO measure related to …