Risk assessment for heroin use and craving score using polygenic risk score

CL Huang, PH Chen, HY Lane, IK Ho… - Journal of Personalized …, 2021 - mdpi.com
… disorder that results from the interaction between biological, … ), tryptophan hydroxylases 1
(TPH1 and 2 TPH2), methadone-… the variant rs2129575 in TPH2 was associated with heroin-…

Association of Functional Polymorphism in TPH2 Gene with Alcohol Dependence and Personality Traits: Study in Cloninger's Type I and Type II Alcohol-Dependent …

M Konjevod, M Rešetar, A Matošić, L Čičin-Šain… - Genes, 2023 - mdpi.com
… The rs4290270 polymorphism has been reported to interact with genetic variants also in …
in the TPH1 gene (encoding a peripheral isoform of TPH) in influencing heroin addiction [43]. …

[HTML][HTML] Association of serotonergic pathway gene polymorphisms with behavioral parameters in patients with opioid dependence

S Sarkar, R Singh, A Sharma, MA Pandit, R Gupta… - Cureus, 2021 - ncbi.nlm.nih.gov
… The deletion variant or short allele is known to reduce the … The sample comprised
predominantly heroin users, though a … A218C and G703T of the TPH1 and TPH2 genes, …

Genetic Variants Associated with Aggressive Behaviour in Humans: The Serotonergic System

PG Mariana de Leão - 2020 - search.proquest.com
… The two variants of TPH1, rs1799913 and rs1800532, … genes/variants, each of small effect,
and their interactions. … been one of the most studied TPH2 variants in AB. Studies indicated …

Candidate gene-environment interactions in substance abuse: A systematic review

Z Jiang, Z Chen, X Chen - Plos one, 2023 - journals.plos.org
… testosterone may interact with MAOA uVNTR variants to … with heroin addiction, and it had
a significant interaction with … [39], there was no interaction between TPH1 or TPH2 gene …

TPH2-703 G/T polymorphism is associated with stress, depression, and psychosocial symptoms in mentally healthy Mexicans

M Hernandez-Mixteco, B Bernal-Morales… - Brain research, 2023 - Elsevier
… enzyme, and genetic variations in the TPH2 gene have been … genes that encode TPH in
humans, TPH1 and TPH2. While … studies should aim to look for possible interactions between …

Sex-dependent complex association of TPH2 with multiple dimensions of ADHD

W Fageera, SM Sengupta, ME Fortier… - Progress in Neuro …, 2021 - Elsevier
… a functional variant in TPH2 (rs17110747) in the pathophysiology of ADHD. This variant has
… There were no statistically significant interactions between rs17110747 and EC, according …

The association of TPH genes with creative insight performance.

J Zhang, S Zhang - Psychology of Aesthetics, Creativity, and the …, 2020 - psycnet.apa.org
… to explore the associations of TPH1 and TPH2 with creative … variants in TPH1 and TPH2, 16
tag SNPs (4 tag SNPs for … may interact with TPH1 to influence creative insight performance. …

Tryptophan and substance abuse: mechanisms and impact

M Davidson, N Rashidi, MK Hossain, A Raza… - International Journal of …, 2023 - mdpi.com
… , heroin, and nicotine are the most commonly used addictive … Tryptophan hydroxylase 1
(TPH1) is known to be composed of … However, recently, it was noted that TPH2 gene variants are …

[PDF][PDF] Genetic variants associated with aggressive behaviour in humans: the serotonergic system

MLPG Pimentel - 2020 - repositorio-aberto.up.pt
… The two variants of TPH1, rs1799913 and rs1800532, … genes/variants, each of small effect,
and their interactions. … been one of the most studied TPH2 variants in AB. Studies indicated …