… with natural products (Section 7) and organic ligands (Section 8)… the most potent hybrid
HA’(10)–THA 476, first described by … Most of the tacripyrines were more potent inhibitors of AChE …

… This review aims to assess the efficacy of acridine- and tacrine-based multi-target hybrid …
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the …

… structure of caffeic acid and tacrine as multitarget-directed ligands against Alzheimer’s disease…
Tacripyrines the first tacrine-dihydropyridine hybrids as multitarget-directed ligands for the …

… Tacripyrines, a new class of hybrid compounds, were developed by combining the calcium
antagonist 1,4-dihydropyridine (DHP) skeleton with the tacrine in … multitarget-directed tacrine …

… These multitarget‐directed ligands are proposed to modify … reported the first GSK‐3β
and HDAC dual inhibitor for AD … reported novel tacrine‐pyrimidone hybrids as dual AChE/GSK‐3β …

… Tacrine, the first drug approved for the treatment of … designed tacrine analogs, especially
the dihydropyridines, … From combinations to multitarget-directed ligands: A continuum in …

… Tacrine was combined with 1,4-Dihydropyridine (1,4-DHP) nimodipine and named as tacripyrine
[66… There are various other semisynthetic drugs, such as tacrinecurcumin hybrid, where …

… Out of all the heterocyclic moiety pyridines, dihydropyridines, and piperidines possess …
Derivatives of pyridine, dihydropyridine, and piperidine are reported to have anti-cancer, …

… In conclusion, a variety of spiro1,4–dihydropyridines are synthesized by various methods …
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitargetdirected ligands for the …

… For example, a tacrine-indole hybrid … ligand for the design of multitarget-directed agents
against AChE and Aβ associated with AD pathology owing to its simple structure and high ligand …