A review of techniques for biodelivery of nerve growth factor (NGF) to the brain in relation to Alzheimer's disease

S Mitra, R Gera, B Linderoth, G Lind… - Recent Advances in …, 2021 - Springer
basal forebrain region (basal forebrain cholinergic neurons, BFCNs) but innervate wide areas
of the brain. … new tools for targeted delivery of neurotrophins to the brain, several important …

[HTML][HTML] Nerve growth factor-based therapy in Alzheimer's disease and age-related macular degeneration

G Amadoro, V Latina, BO Balzamino, R Squitti… - Frontiers in …, 2021 - frontiersin.org
nerve growth factor (NGF) signaling, metabolism, and/or defect in NGF transport to the basal
forebrain cholinergic … EC-NGF biodelivery devices targeting the basal forebrain of implanted …

[HTML][HTML] Synergic treatment of Alzheimer's disease with brain targeted nanoparticles incorporating NgR-siRNA and brain derived neurotrophic factor

Z Wang, Y Cheng, D Zhao, A Pliss, J Liu… - Smart Materials in …, 2020 - Elsevier
brain-targeted modification, the nanoparticles overcome the blood-brain barrier were delivered
into the basal forebrain … action of central cholinergic neuronal regeneration, and BDNF …

A Review of Techniques for Biodelivery of Nerve Growth Factor (NGF) to the Brain in Relation to AlzheimerTs

S Mitra, R Gera, B Linderoth, G Lind, L Wahlberg… - Recent Advances in NGF … - Springer
… in the basal forebrain region (basal forebrain cholinergic … tools for targeted delivery of
neurotrophins to the brain, several … of Alzheimer disease in basal forebrain cholinergic neurons: …

Gene and cell therapy for the nucleus basalis of Meynert with NGF in Alzheimer's disease

M Eriksdotter, S Mitra - Handbook of Clinical Neurology, 2021 - Elsevier
… of acetylcholine-esterase targeting the cholinergic system with … cholinergic system in AD
focusing on nerve growth factor (… is required for the survival and function of the basal forebrain

Nerve growth factor gene delivery across the blood–brain barrier to reduce beta amyloid accumulation in AD mice

BDS Rodrigues, T Kanekiyo, J Singh - Molecular Pharmaceutics, 2020 - ACS Publications
nerve growth factor (NGF) gene using brain-targeted liposomal nanoparticles was investigated
for the treatment of Alzheimers disease … of basal forebrain cholinergic neurons. (5−7) It …

Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer's disease

K Xhima, K Markham-Coultes, H Nedev, S Heinen… - Science …, 2020 - science.org
… aging, nerve growth factor (NGF) enhances cholinergic cell … achieved noninvasive delivery
of D3 to the basal forebrain in … is an effective method for targeted drug delivery to the basal

Nerve growth factor: Influence on cholinergic neurons in the CNS

C Eva - CNS Neurotransmitters and Neuromodulators, 2020 - taylorfrancis.com
Target derived growth factors that regulate neuronal survival … factor for cholinergic neurons
located in basal forebrain and … of cholinergic neurons in the basal forebrain in Alzheimers

[HTML][HTML] Peptides derived from growth factors to treat Alzheimer's disease

S Gascon, J Jann, C Langlois-Blais, M Plourde… - International Journal of …, 2021 - mdpi.com
… can target selective signaling pathways involved in neuron … dysregulation of the cholinergic
system in the basal forebrain, a … of neurotrophic factors (nerve growth factor (NGF) and brain-…

Postmortem analysis in a clinical trial of AAV2-NGF gene therapy for Alzheimer's disease identifies a need for improved vector delivery

MJ Castle, FC Baltanás, I Kovacs… - Human gene …, 2020 - liebertpub.com
… AAV2-NGF successfully engaged the target cholinergic neurons of the basal forebrain. In this
study, … by loss of cholinergic neurons in the basal forebrain. Nerve growth factor (NGF) is an …