[HTML][HTML] Elevated levels of miR-144-3p induce cholinergic degeneration by impairing the maturation of NGF in Alzheimer's disease

LT Zhou, J Zhang, L Tan, HZ Huang, Y Zhou… - Frontiers in cell and …, 2021 - frontiersin.org
Nerve growth factor (NGF) is secreted in brain regions that receive projections from the basal
forebrain cholinergic … degeneration in AD and identified a potential therapeutic target for AD…

[HTML][HTML] Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential

L Gao, Y Zhang, K Sterling, W Song - Translational neurodegeneration, 2022 - Springer
… of how BDNF genomic structure is connected to factors that regulate BDNF signaling. We
then discuss the role of BDNF in AD and the potential of BDNF-targeting therapeutics for AD. …

Nanoparticlized system: promising approach for the management of Alzheimer's disease through intranasal delivery

S Bahadur, N Sachan, RK Harwansh… - Current …, 2020 - ingentaconnect.com
factors like insulin growth factors, nerve growth factors, … Further, AD linked with acetylcholine
and cholinergic neurons, … for drug delivery to brain, among them intranasal drug delivery

[HTML][HTML] The involvement of insulin-like growth factor 1 and nerve growth factor in alzheimer's disease-like pathology and survival role of the mix of embryonic …

M Aghajanov, S Matinyan, V Chavushyan… - International Journal of …, 2021 - mdpi.com
… , we aimed to identify the involvement of neurotrophic factors—the insulin-like growth factor
1 (IGF-1) and nerve growth factor (… Selective degeneration of the nucleus basalis cholinergic

[HTML][HTML] Increased endogenous GDNF in mice protects against age-related decline in neuronal cholinergic markers

S Mitra, G Turconi, T Darreh-Shori, K Mätlik… - Frontiers in aging …, 2021 - frontiersin.org
… types of dementia, including Alzheimers disease (AD), Lewy … the level of nerve growth factor
(NGF), which is important for … significantly lower Cholinergic index in basal forebrain (about …

Intranasal drug delivery for treatment of Alzheimer's disease

LC Fonseca, JA Lopes, J Vieira, C Viegas… - Drug Delivery and …, 2021 - Springer
… of nervous impulses in the synapses cholinergic fibers by hydrolysis of acetylcholine (ACh) …
, or proteins (eg, insulin, human growth hormone, interferon) to improve their absorption and …

[HTML][HTML] Recent advances in the treatment of Alzheimer's disease using nanoparticle-based drug delivery systems

P Poudel, S Park - Pharmaceutics, 2022 - mdpi.com
Cholinergic Deficit During the progression of AD, cholinergic neurons in the basal forebrain
… (Ru) as a carrier, which was loaded with nerve growth factor (NGF) and sealed with a phase …

Gene therapy in Alzheimer disease patients

M ERIKSDOTTER-JÖNHAGEN, B LINDEROTH… - Gene therapy - degruyter.com
delivery of NGF to the cholinergic basal forebrain can arrest and even reverse the degeneration
of the basal forebrain cholinergic … and intracerebroventricular drug delivery by infusion …

Intravenous and non-invasive drug delivery to the mouse basal forebrain using MRI-guided focused ultrasound

K Xhima, D McMahon, E Ntiri, M Goubran… - Bio …, 2021 - bio-protocol.org
cholinergic-based therapies is not only the production of biologically active compounds but
also a platform for safe and efficient drug delivery to the basal forebrainAlzheimers disease (…

The NGF metabolic pathway: New opportunities for biomarker research and drug target discovery: NGF pathway biomarkers and drug targets

R Pentz, MF Iulita - Recent Advances in NGF and Related Molecules: The …, 2021 - Springer
… mediator of Alzheimers disease (AD) symptoms, may play a disease-… of basal forebrain
cholinergic neurons in AD as the result of pathological alterations to nerve growth factor (NGF) …