[HTML][HTML] Live-Cell Cardiac-Specific High-Throughput Screening Platform for Drug-Like Molecules That Enhance Ca2+ Transport
TM Schaaf, E Kleinboehl, SL Yuen, LN Roelike… - Cells, 2020 - mdpi.com
… with insufficient activity of the sarcoplasmic reticulum Ca-pump (… gene therapy to enhance
SERCA2a expression in the heart … The goals of this study were focused on drug discovery, but …
SERCA2a expression in the heart … The goals of this study were focused on drug discovery, but …
[HTML][HTML] Attenuation of the upregulation of NF‑κB and AP‑1 DNA‑binding activities induced by tunicamycin or hypoxia/reoxygenation in neonatal rat cardiomyocytes by …
Z Qu, X Lu, Y Qu, T Tao, X Liu… - … journal of molecular …, 2021 - spandidos-publications.com
… The present study aimed to investigate the effects of the … + from the cytosol to the sarcoplasmic
reticulum (SR) lumen … ), rAAV1-mediated intracoronary gene transfer in vivo has been …
reticulum (SR) lumen … ), rAAV1-mediated intracoronary gene transfer in vivo has been …
Pathophysiology and treatment of hypertrophic cardiomyopathy: new perspectives
M Zampieri, M Berteotti, C Ferrantini, L Tassetti… - Current heart failure …, 2021 - Springer
… evidences, a subsequent phase II open-label study in … novel molecules that target sarcoplasmic
reticulum function. … be amenable to gene therapy on a significant scale in the near future. …
reticulum function. … be amenable to gene therapy on a significant scale in the near future. …
Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure …
… ) is a protein in the sarcoplasmic reticulum membrane that … to repair the genetic defect (eg
antisense and gene therapy), … expression of a stable dystrophin gene. Functional assessment, …
antisense and gene therapy), … expression of a stable dystrophin gene. Functional assessment, …
Compound SJ-12 attenuates streptozocin-induced diabetic cardiomyopathy by stabilizing SERCA2a
S Lou, W Zhu, T Yu, Q Zhang, M Wang, L Jin… - … et Biophysica Acta (BBA …, 2024 - Elsevier
… Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2a (… of calcium ions into the
sarcoplasmic reticulum, which is … results showed that SP1 and its target genes (Ryr2, Slc8a1/…
sarcoplasmic reticulum, which is … results showed that SP1 and its target genes (Ryr2, Slc8a1/…
Basic science of cardiac contractility modulation therapy: molecular and electrophysiological mechanisms
D Masarone, MM Kittleson, A D'Onofrio, L Falco… - Heart Rhythm, 2023 - Elsevier
… Despite significant advances in drug therapy for HF with reduced … of elevated Ca2+/calmodulin-dependent
protein kinase II … in the sarcoplasmic reticulum Ca ++ cycle and stretch …
protein kinase II … in the sarcoplasmic reticulum Ca ++ cycle and stretch …
Changes in cellular Ca2+ and Na+ regulation during the progression towards heart failure
KT MacLeod - The Journal of Physiology, 2023 - Wiley Online Library
… Uptake of Ca 2+ into the sarcoplasmic reticulum (SR) is reduced because of … targeting.
First, it has been demonstrated that SERCA2a gene transfer into myocytes from failing hearts …
First, it has been demonstrated that SERCA2a gene transfer into myocytes from failing hearts …
[PDF][PDF] Gene therapy with phosphodiesterases 2A and 4B in a murine model of pressure overload-induced cardiac hypertrophy
N Pavlaki - 2021 - ediss.sub.uni-hamburg.de
… on cAMP dynamics in membrane- and sarcoplasmic reticulum… The results suggest that
cardiac-targeted gene therapy with … , gene therapy could be also successfully utilized in restoring …
cardiac-targeted gene therapy with … , gene therapy could be also successfully utilized in restoring …
[HTML][HTML] AAV-mediated gene therapy: Advancing cardiovascular disease treatment
H Zhang, Q Zhan, B Huang, Y Wang… - Frontiers in …, 2022 - frontiersin.org
… as gene delivery vectors with improved specific targeting … pH environment, and the
phospholipase A2 domain of the capsid … sarcoplasmic reticulum calcium ATPase (SERCA2a) …
phospholipase A2 domain of the capsid … sarcoplasmic reticulum calcium ATPase (SERCA2a) …
[HTML][HTML] A-kinase anchoring proteins in cardiac myocytes and their roles in regulating calcium cycling
H Subramanian, VO Nikolaev - Cells, 2023 - mdpi.com
… SR via the sarcoplasmic reticulum Ca2+ ATPase 2a (SERCA2a… , targeting gravin is proposed
as a therapy for heart failure. … Though gene therapy to express SERCA2a improved cardiac …
as a therapy for heart failure. … Though gene therapy to express SERCA2a improved cardiac …