… , most investigations have focused on the main calcium … kinase II type could modulate the
RyR activity as part of the Ca 2+ -… improving its stability and modulating its function in the heart […

… cardiac output… stability, further optimization is required and should be considered in future
studies [149]. In 2015, a monthly repeat-dose phase II CFTR non-viral (liposome) gene transfer …

… of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in … Targeted
sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart…

… through direct interaction and its target RalA. Deletion of … and activates the pump for
sarcoplasmic reticulum calcium re-uptake… AAV-mediated gene transfer of SERCA2 improves …

… i) marked DD not associated to cardiac fibrosis, (ii) LV mass reduction … an impairment of
sarcoplasmic reticulum (SR) Ca 2+ refilling … small molecules or gene therapy aimed at selectively …

… In Phase II, we generated new AAV vectors with various … the cardiac isoform of sarcoplasmic
reticulum calcium ATPase (… SERCA2a expression via gene transfer has been shown by our …

… Gene transfer offers an option to treat the mutated or failing … the release of more Ca 2+ from
stores in the sarcoplasmic reticulum (SR) … Lilac stars indicate the main gene therapy targets. …

… represent interesting targets to gain more insights in heart … + re-uptake via the sarcoplasmic
reticulum Ca 2+ ATPase (… to induce cardiac hypertrophy, AAV-mediated I-1c gene transfer …

… data suggest that also targeting metabolism may provide … of heart failure, no treatment that
targets reactive oxygen species (ROS) directly has entered the clinical arena yet. In the heart, …

… efficacy and specifically target profibrotic pathways in … systolic and diastolic dysfunction
(stage II), systolic and diastolic … , Ca 2+ moves back into the sarcoplasmic reticulum and the …