… associated with heart failure or electrical instabilities are … from treatments aimed to restore
cardiac redox homeostasis. … and electrical instability which manifest as impaired cardiac …

… therapeutic target in sudden cardiac death and heart failure. … , the expression level of
sarcoplasmic reticulum (SR) Ca 2+ -… II (CaMKII) activation] triggers the increased diastolic SR …

… of targeted regulation of mitochondrial function on skeletal muscle atrophy, including drug
therapy, exercise and diet, gene therapy… challenge in skeletal muscle regeneration and repair. …

… as a gene transfer vector in clinical trials for heart failure and in … demonstrated that
Sarcoplasmic reticulum Ca 2+ -ATPase 2a (… Collectively, this study suggested that targeting DNA …

… for short-term stabilization of cardiac workload. However, … In order to target NRVCMs, both
transgenes were expressed … in transgene expression (Figure 2A) and moreover an expression-…

… phosphorylated-Ca 2+ /calmodulin-dependent protein kinase II in … (RyR2) -mediated
sarcoplasmic reticulum (SR) Ca 2+ leakage [… of Ca 2+ handling by targeted SERCA2a gene …

… pharmacological treatment options targeting mitochondria to … diastolic calcium leak from the
sarcoplasmic reticulum (SR) due … of AF [64], and gene therapy directed at the improvement of …

… can further stimulate Ca2+/calmodulin-dependent inase II (… virus (rAAVs)-mediated gene
transfer emerged as a viable option … increase the sarcoplasmic reticulum (SR) Ca2+ transients …

… curbing its proclivity for cardiac compromise. These stratagems … II-DNA cleavage complexes
and induces the stabilization of … a stable compound that can specifically target cancer cells …

… 2) on sarcoplasmic reticulum (SR) and aberrant Ca 2+ cycling … and hypertrophic target
genes. CaMKII not only changes the … The drug achieves the stabilization effect by binding to the …