… of TGF-β and its downstream molecules in the progression of fibrosis and cancers, therapeutics
targeting TGF-β signaling … , the development of TGF-β therapeutics has lagged. In this …

… that may benefit from TGFβ targeting is urgently needed. In this review, we … cancer
treatment, and provide perspectives of combined treatment to overcome chemo/targeted/radio-therapy …

… Agents targeting TGF-β signal pathway have shown promising prospects in cancer therapy.
… achievements of TGF-β blockades used or being evaluated in cancer therapy, providing us …

… This is an indication that TGF-β might be a target for tumor therapy. 3.2 TGF-β as tumor …
, further clinical trials will help define drugs that target the TGF-β activity in cancer treatment. …

… clinical studies of TGF-β signaling in regulating cancer drug resistance, … target TGF-β-mediated
drug resistance in cancer patients. TGF-β Signaling and Resistance to Targeted Therapy …

… To evaluate GC1008 in cancer treatment, a phase I study (… pharmacodynamics in patients
with advanced renal cell carcinoma (… TβM1, a human monoclonal antibody that targets TGF-β1, …

… Cancer arises from malignant cells that exist in dynamic … Cancer therapies aiming to directly
kill cancer cells, including oncogene-targeted therapy and immune-checkpoint therapy that …

… , for colon cancer patients who failed entire body anticancer treatment based on RECIST
and iRECIST (primary and secondary anticancer evaluation indices). Colon cancer patients …

… cancer patients. Specifically, we focus on (i) the dual roles of TGF-β signaling in cancer
metastasis; (ii) dynamic signaling… to treat cancer patients by blocking TGF-β signaling pathway by …

… available clinical data on therapy based on inhibiting TGF-β signaling for the treatment of …
Targeted therapy is a type of cancer treatment using drugs targeting particular molecules …